Accession ARO:3003820
CARD Short NamemgrB
DefinitionmgrB is a small transmembrane protein produced in the PhoPQ signalling system. It acts as a negative regulator in this system. Inactivation or down-regulation of mgrB confers colistin resistance by absence as shown in Klebsiella pneumoniae.
AMR Gene Familytransmembrane protein conferring colistin resistance
Drug Classpeptide antibiotic
Resistance Mechanismresistance by absence
Classification10 ontology terms | Show
Parent Term(s)3 ontology terms | Show
+ transmembrane protein conferring colistin resistance [AMR Gene Family]
+ confers_resistance_to_antibiotic colistin B [Antibiotic]
+ confers_resistance_to_antibiotic colistin A [Antibiotic]
1 ontology terms | Show
+ phoPQ regulates

Poirel L, et al. 2015. J. Antimicrob. Chemother. 70(1):75-80 The mgrB gene as a key target for acquired resistance to colistin in Klebsiella pneumoniae. (PMID 25190723)

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