phoPQ

Accession ARO:3000821
Synonym(s)PhoP/Q
DefinitionPhoPQ is a two-component regulatory system. phoP is phosphorylated by phoQ at a low [mg2+], activating the repressor. Its part of a two component regulating system that activates the PmrA/B system which has downstream effects, leading to Antimicrobial resistance in many pathogens. In Salmonella, phoP bind to macAB ABC transporter and represses it. In Escherichia coli, phoPQ regulates arnA expression. In Pseudomonas aeruginosa, phoPQ regulates OprH expression. phoPQ have other roles in other species.
AMR Gene Familypmr phosphoethanolamine transferase, ATP-binding cassette (ABC) antibiotic efflux pump
Drug Classpeptide antibiotic, macrolide antibiotic
Resistance Mechanismantibiotic target alteration, antibiotic efflux
Efflux Componentefflux pump complex or subunit conferring antibiotic resistance
Efflux Regulatorprotein(s) and two-component regulatory system modulating antibiotic efflux
Classification19 ontology terms | Show
Parent Term(s)5 ontology terms | Show
+ confers_resistance_to_drug_class peptide antibiotic [Drug Class]
+ protein(s) and two-component regulatory system modulating antibiotic efflux [Efflux Regulator]
+ regulates MacAB-TolC
+ regulates arnA
+ regulates basRS
Sub-Term(s)
3 ontology terms | Show
+ phoP part_of
+ phoQ part_of
+ mgrB regulates
Publications

Nishino K, et al. 2005. Mol Microbiol 59(1): 126-141. Virulence and drug resistance roles of multidrug efflux systems of Salmonella enterica serovar Typhimurium. (PMID 16359323)

Groisman EA and Groisman EA. 2001. J Bacteriol 183(6): 1835-1842. The pleiotropic two-component regulatory system PhoP-PhoQ. (PMID 11222580)

Falagas ME, et al. 2010. Drug Resist Updat 13(4-5): 132-138. Resistance to polymyxins: Mechanisms, frequency and treatment options. (PMID 20843473)

Landman D, et al. 2011. J. Antimicrob. Chemother. 66(2):332-4 Antimicrobial activity of a novel aminoglycoside, ACHN-490, against Acinetobacter baumannii and Pseudomonas aeruginosa from New York City. (PMID 21131322)