Accession ARO:3000821
DefinitionPhoPQ is a two-component regulatory system. phoP is phosphorylated by phoQ at a low [mg2+], activating the repressor. Its part of a two component regulating system that activates the PmrA/B system which has downstream effects, leading to Antimicrobial resistance in many pathogens. In Salmonella, phoP bind to macAB ABC transporter and represses it. In Escherichia coli, phoPQ regulates arnA expression. In Pseudomonas aeruginosa, phoPQ regulates OprH expression. phoPQ have other roles in other species.
AMR Gene Familypmr phosphoethanolamine transferase, transmembrane protein conferring colistin resistance, ATP-binding cassette (ABC) antibiotic efflux pump
Drug Classpeptide antibiotic, macrolide antibiotic
Resistance Mechanismantibiotic target alteration, resistance by absence, antibiotic efflux
Efflux Componentefflux pump complex or subunit conferring antibiotic resistance
Efflux Regulatorprotein(s) and two-component regulatory system modulating antibiotic efflux
Classification29 ontology terms | Show
Parent Term(s)6 ontology terms | Show
+ protein(s) and two-component regulatory system modulating antibiotic efflux [Efflux Regulator]
+ regulates MacAB-TolC
+ regulates basRS
+ confers_resistance_to_drug_class peptide antibiotic [Drug Class]
+ regulates mgrB
+ regulates arnA
2 ontology terms | Show
+ phoP part_of
+ phoQ part_of

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Groisman EA and Groisman EA. 2001. J Bacteriol 183(6): 1835-1842. The pleiotropic two-component regulatory system PhoP-PhoQ. (PMID 11222580)

Falagas ME, et al. 2010. Drug Resist Updat 13(4-5): 132-138. Resistance to polymyxins: Mechanisms, frequency and treatment options. (PMID 20843473)

Landman D, et al. 2011. J. Antimicrob. Chemother. 66(2):332-4 Antimicrobial activity of a novel aminoglycoside, ACHN-490, against Acinetobacter baumannii and Pseudomonas aeruginosa from New York City. (PMID 21131322)