| Accession | ARO:3000821 |
| Synonym(s) | PhoP/Q |
| Definition | PhoPQ is a two-component regulatory system. phoP is phosphorylated by phoQ at a low [mg2+], activating the repressor. Its part of a two component regulating system that activates the PmrA/B system which has downstream effects, leading to Antimicrobial resistance in many pathogens. In Salmonella, phoP bind to macAB ABC transporter and represses it. In Escherichia coli, phoPQ regulates arnA expression. In Pseudomonas aeruginosa, phoPQ regulates OprH expression. phoPQ have other roles in other species. |
| AMR Gene Family | pmr phosphoethanolamine transferase, transmembrane protein conferring colistin resistance, ATP-binding cassette (ABC) antibiotic efflux pump |
| Drug Class | peptide antibiotic, macrolide antibiotic |
| Resistance Mechanism | antibiotic target alteration, resistance by absence, antibiotic efflux |
| Efflux Component | efflux pump complex or subunit conferring antibiotic resistance |
| Efflux Regulator | protein(s) and two-component regulatory system modulating antibiotic efflux |
| Classification | 29 ontology terms | Show + process or component of antibiotic biology or chemistry + mechanism of antibiotic resistance + antibiotic molecule + antibiotic target alteration [Resistance Mechanism] + peptide antibiotic [Drug Class] + charge alteration conferring antibiotic resistance + determinant of antibiotic resistance + lipopeptide antibiotic + gene altering cell wall charge + antibiotic mixture + resistance by absence [Resistance Mechanism] + antibiotic efflux [Resistance Mechanism] + phosphoethanolamine transferase conferring colistin resistance + polymyxin antibiotic + pmr phosphoethanolamine transferase [AMR Gene Family] + efflux pump complex or subunit conferring antibiotic resistance [Efflux Component] + colistin + gene conferring resistance via absence + polymyxin B [Antibiotic] + macrolide antibiotic [Drug Class] + protein(s) and two-component regulatory system modulating antibiotic efflux [Efflux Regulator] + transmembrane protein conferring colistin resistance [AMR Gene Family] + PmrF + arnA + ugd + ATP-binding cassette (ABC) antibiotic efflux pump [AMR Gene Family] + colistin B [Antibiotic] + erythromycin [Antibiotic] + colistin A [Antibiotic] |
| Parent Term(s) | 6 ontology terms | Show + protein(s) and two-component regulatory system modulating antibiotic efflux [Efflux Regulator] + regulates MacAB-TolC + regulates basRS + confers_resistance_to_drug_class peptide antibiotic [Drug Class] + regulates mgrB + regulates arnA |
| Sub-Term(s) | 2 ontology terms | Show |
| Publications | Nishino K, et al. 2005. Mol Microbiol 59(1): 126-141. Virulence and drug resistance roles of multidrug efflux systems of Salmonella enterica serovar Typhimurium. (PMID 16359323) Groisman EA and Groisman EA. 2001. J Bacteriol 183(6): 1835-1842. The pleiotropic two-component regulatory system PhoP-PhoQ. (PMID 11222580) Falagas ME, et al. 2010. Drug Resist Updat 13(4-5): 132-138. Resistance to polymyxins: Mechanisms, frequency and treatment options. (PMID 20843473) Landman D, et al. 2011. J. Antimicrob. Chemother. 66(2):332-4 Antimicrobial activity of a novel aminoglycoside, ACHN-490, against Acinetobacter baumannii and Pseudomonas aeruginosa from New York City. (PMID 21131322) |