Accession ARO:3000545
DefinitionMacAB-TolC is an ABC efflux pump complex expressed in E. coli and Salmonella enterica. It confers resistance to macrolides, including erythromycin.
AMR Gene FamilyATP-binding cassette (ABC) antibiotic efflux pump
Drug Classmacrolide antibiotic
Resistance Mechanismantibiotic efflux
Efflux Componentefflux pump complex or subunit conferring antibiotic resistance
Classification7 ontology terms | Show
Parent Term(s)2 ontology terms | Show
+ ATP-binding cassette (ABC) antibiotic efflux pump [AMR Gene Family]
+ confers_resistance_to_antibiotic erythromycin [Antibiotic]
4 ontology terms | Show
+ macA part_of
+ macB part_of
+ TolC part_of
+ phoPQ regulates

Nishino K, et al. 2005. Mol Microbiol 59(1): 126-141. Virulence and drug resistance roles of multidrug efflux systems of Salmonella enterica serovar Typhimurium. (PMID 16359323)