basRS

Accession ARO:3003579
Synonym(s)pmrAB
DefinitionBasRS is a two-component regulatory system. BasR is phosphorylated by BasS at high[Fe3+] levels. The BasRS system regulates the expression of pmrE, pmrF and pmrC, leading to antibiotic resistance.
AMR Gene Familypmr phosphoethanolamine transferase
Drug Classpeptide antibiotic
Resistance Mechanismantibiotic target alteration, antibiotic efflux
Efflux Regulatorprotein(s) and two-component regulatory system modulating antibiotic efflux
Classification15 ontology terms | Show
Parent Term(s)4 ontology terms | Show
+ regulates ugd
+ protein(s) and two-component regulatory system modulating antibiotic efflux [Efflux Regulator]
+ regulates PmrF
+ regulates arnA
Sub-Term(s)
3 ontology terms | Show
+ phoPQ regulates
+ basS part_of
+ basR part_of
Publications

Lee JY, et al. 2014. Diagn Microbiol Infect Dis 78(3): 271-276. Mutations and expression of PmrAB and PhoPQ related with colistin resistance in Pseudomonas aeruginosa clinical isolates. (PMID 24412662)