| Accession | ARO:3003583 |
| Synonym(s) | pmrB |
| CARD Short Name | basS |
| Definition | Histidine protein kinase sensor Lipid A modification gene; part of a two-component system involved in polymyxin resistance that senses high extracellular Fe(2+). |
| AMR Gene Family | pmr phosphoethanolamine transferase |
| Drug Class | peptide antibiotic |
| Resistance Mechanism | antibiotic target alteration, antibiotic efflux |
| Efflux Regulator | protein(s) and two-component regulatory system modulating antibiotic efflux |
| Resistomes with Perfect Matches | Pseudomonas aeruginosag+p+wgs, Pseudomonas fluorescensg |
| Resistomes with Sequence Variants | Pseudomonas aeruginosag+p+wgs, Pseudomonas fluorescensg |
| Classification | 19 ontology terms | Show + process or component of antibiotic biology or chemistry + mechanism of antibiotic resistance + antibiotic target alteration [Resistance Mechanism] + antibiotic molecule + peptide antibiotic [Drug Class] + charge alteration conferring antibiotic resistance + determinant of antibiotic resistance + lipopeptide antibiotic + gene altering cell wall charge + phosphoethanolamine transferase conferring colistin resistance + antibiotic mixture + polymyxin antibiotic + pmr phosphoethanolamine transferase [AMR Gene Family] + polymyxin B [Antibiotic] + antibiotic efflux [Resistance Mechanism] + PmrF + arnA + protein(s) and two-component regulatory system modulating antibiotic efflux [Efflux Regulator] + ugd |
| Parent Term(s) | 2 ontology terms | Show |
| Publications | Lean SS, et al. 2014. ISRN Microbiol 2014: 953417. Prevalence and Genetic Characterization of Carbapenem- and Polymyxin-Resistant Acinetobacter baumannii Isolated from a Tertiary Hospital in Terengganu, Malaysia. (PMID 25006521) McPhee JB, et al. 2003. Mol. Microbiol. 50(1):205-17 Cationic antimicrobial peptides activate a two-component regulatory system, PmrA-PmrB, that regulates resistance to polymyxin B and cationic antimicrobial peptides in Pseudomonas aeruginosa. (PMID 14507375) |
Prevalence of basS among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 413 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).
| Species | NCBI Chromosome | NCBI Plasmid | NCBI WGS | NCBI GI |
|---|---|---|---|---|
| Pseudomonas aeruginosa | 97.7% | 0.29% | 66.86% | 0% |
| Pseudomonas fluorescens | 2.78% | 0% | 0% | 0% |
Model Type: protein homolog model
Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.
Bit-score Cut-off (blastP): 900