| Accession | ARO:3003581 |
| Definition | These genes are involved in the biosynthesis of lipid A in Gram-negative bacteria and mutations to this gene may cause resistance to antimicrobial peptides that target the outer membrane. Mutation by absence or insertion of ISAba11 sequence is a known cause of resistance in Acinetobacter baumanniiâ–¿. |
| Drug Class | peptide antibiotic |
| Resistance Mechanism | antibiotic target alteration |
| Classification | 11 ontology terms | Show + process or component of antibiotic biology or chemistry + antibiotic molecule + peptide antibiotic [Drug Class] + lipopeptide antibiotic + mechanism of antibiotic resistance + antibiotic target alteration [Resistance Mechanism] + polymyxin antibiotic + restructuring of bacterial cell wall conferring antibiotic resistance + mutation conferring antibiotic resistance + determinant of antibiotic resistance + colistin |
| Parent Term(s) | 5 ontology terms | Show + antibiotic resistant gene variant or mutant + protein(s) conferring antibiotic resistance via molecular bypass + confers_resistance_to_drug_class peptide antibiotic [Drug Class] + confers_resistance_to_antibiotic colistin A [Antibiotic] + confers_resistance_to_antibiotic colistin B [Antibiotic] |
| Sub-Term(s) | 3 ontology terms | Show |
| Publications | Beceiro A, et al. 2013. Antimicrob Agents Chemother 58(1): 518-526. Biological cost of different mechanisms of colistin resistance and their impact on virulence in Acinetobacter baumannii. (PMID 24189257) Moffatt JH, et al. 2011. Antimicrob Agents Chemother 55(6): 3022-3024. Insertion sequence ISAba11 is involved in colistin resistance and loss of lipopolysaccharide in Acinetobacter baumannii. (PMID 21402838) |