Acinetobacter mutant Lpx gene conferring resistance to colistin [AMR Gene Family]

Accession ARO:3003581
DefinitionThese genes are involved in the biosynthesis of lipid A in Gram-negative bacteria and mutations to this gene may cause resistance to antimicrobial peptides that target the outer membrane. Mutation by absence or insertion of ISAba11 sequence is a known cause of resistance in Acinetobacter baumanniiâ–¿.
Drug Classpeptide antibiotic
Resistance Mechanismantibiotic target alteration
Classification11 ontology terms | Show
Parent Term(s)5 ontology terms | Show
+ protein(s) conferring antibiotic resistance via molecular bypass
+ antibiotic resistant gene variant or mutant
+ confers_resistance_to_antibiotic colistin A [Antibiotic]
+ confers_resistance_to_antibiotic colistin B [Antibiotic]
+ confers_resistance_to_drug_class peptide antibiotic [Drug Class]
3 ontology terms | Show
+ LpxA
+ LpxC
+ LpxD

Beceiro A, et al. 2013. Antimicrob Agents Chemother 58(1): 518-526. Biological cost of different mechanisms of colistin resistance and their impact on virulence in Acinetobacter baumannii. (PMID 24189257)

Moffatt JH, et al. 2011. Antimicrob Agents Chemother 55(6): 3022-3024. Insertion sequence ISAba11 is involved in colistin resistance and loss of lipopolysaccharide in Acinetobacter baumannii. (PMID 21402838)