| Accession | ARO:3004466 |
| CARD Short Name | ICR-Mc |
| Definition | A chromosomally-encoded colistin resistance phosphoethanolamine (PEtN) transferase of Moraxella catarrhalis. ICR-Mc is the protein that represents the closest known ortholog to the colistin resistance MCR-1 and MCR-2 PEtN transferases. |
| AMR Gene Family | intrinsic colistin resistant phosphoethanolamine transferase |
| Drug Class | peptide antibiotic |
| Resistance Mechanism | antibiotic target alteration |
| Resistomes with Perfect Matches | Moraxella catarrhalisg+wgs |
| Resistomes with Sequence Variants | Moraxella catarrhalisg+wgs |
| Classification | 12 ontology terms | Show + process or component of antibiotic biology or chemistry + antibiotic molecule + mechanism of antibiotic resistance + peptide antibiotic [Drug Class] + antibiotic target alteration [Resistance Mechanism] + charge alteration conferring antibiotic resistance + lipopeptide antibiotic + determinant of antibiotic resistance + gene altering cell wall charge + polymyxin antibiotic + phosphoethanolamine transferase conferring colistin resistance + colistin |
| Parent Term(s) | 3 ontology terms | Show + confers_resistance_to_antibiotic colistin A [Antibiotic] + confers_resistance_to_antibiotic colistin B [Antibiotic] + intrinsic colistin resistant phosphoethanolamine transferase [AMR Gene Family] |
| Publications | Stogios PJ, et al. 2018. ACS Chem. Biol. 13(5):1322-1332 Substrate Recognition by a Colistin Resistance Enzyme from Moraxella catarrhalis. (PMID 29631403) |
Prevalence of ICR-Mc among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 413 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).
| Species | NCBI Chromosome | NCBI Plasmid | NCBI WGS | NCBI GI |
|---|---|---|---|---|
| Moraxella catarrhalis | 100% | 0% | 93.26% | 0% |
Model Type: protein homolog model
Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.
Bit-score Cut-off (blastP): 600
Type of Antibiotic Resistance: Intrinsic or chromosomally-encoded