ICR-Mc

Accession ARO:3004466
DefinitionA chromosomally-encoded colistin resistance phosphoethanolamine (PEtN) transferase of Moraxella catarrhalis. ICR-Mc is the protein that represents the closest known ortholog to the colistin resistance MCR-1 and MCR-2 PEtN transferases.
AMR Gene Familyintrinsic colistin resistant phosphoethanolamine transferase
Drug Classpeptide antibiotic
Resistance Mechanismantibiotic target alteration
ResistomesMoraxella catarrhalisg+wgs
Classification13 ontology terms | Show
Parent Term(s)3 ontology terms | Show
+ confers_resistance_to_antibiotic colistin A [Antibiotic]
+ confers_resistance_to_antibiotic colistin B [Antibiotic]
+ intrinsic colistin resistant phosphoethanolamine transferase [AMR Gene Family]
Publications

Stogios PJ, et al. 2018. ACS Chem. Biol. 13(5):1322-1332 Substrate Recognition by a Colistin Resistance Enzyme from Moraxella catarrhalis. (PMID 29631403)

Resistomes

Prevalence of ICR-Mc among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI for 82 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).

Prevalence: protein homolog model (view sequences)

SpeciesNCBI ChromosomeNCBI PlasmidNCBI WGS
Moraxella catarrhalis100%0%95.74%
Show Perfect Only


Detection Models

Model Type: protein homolog model

Model Definition: The protein homolog model is an AMR detection model. Protein homolog models detect a protein sequence based on its similarity to a curated reference sequence. A protein homolog model has only one parameter: a curated BLASTP bitscore cutoff for determining the strength of a match. Protein homolog model matches to reference sequences are categorized on three criteria: perfect, strict and loose. A perfect match is 100% identical to the reference sequence along its entire length; a strict match is not identical but the bitscore of the matched sequence is greater than the curated BLASTP bitscore cutoff. Loose matches are other sequences with a match bitscore less than the curated BLASTP bitscore.

Bit-score Cut-off (blastP): 600

Type of Antibiotic Resistance: Intrinsic or chromosomally-encoded


>gb|EGE18576.1|-|ICR-Mc [Moraxella catarrhalis BC1]
MSLKHNQTHNTTFTKFLKSNSFWSKGFWSNRHHRTKDLKGLDAYLFMAIVAIFLTTTANVTFFQQVMSVYPLANYAPFIASLAVVLTGVL
LLLLVLLGYRHTLKTVAICFILIAAFAGHFTDTYGTVYDTTMLQNALQTDTAETKDLLSMKLLIRVVLLAGLPICWIIGQPLSFGTLKAS
LMKRLVTYLVALALVGLPILAFSSQYASFFREHKPLRFFTNPVTVMYSAGKLANMSYKNATKPTETIMHANDAIQKTTASTRKPRLVVMV
VGETARADHASFNGYQRATFPHMDKLIGLGQVHNFGNVTSCGTSTAYSVPCMFSYLGAEKYDVDTADYHENVIDTLDRLGVAILWRDNNS
DSKGVMNRLPAKQYQDYKNSPLQGGNNTICHTNPYDECRDVGMLVDLDDHVKAHANQDILIVLHQMGNHGPAYYKRYDDEFAQFLPVCTS
SELAECERQTVINAYDNALLATDDFLKQTIDWLAAQTHADTAMLYLSDHGESLGEKGVYLHGMPKAFAPKEQLSIPALLWLGADTPFAVA
NSPTAGFSHDAITPTLLNLFDVSTQATADKTAFVNPLD


>gb|AERH01000018.1|-|16204-17940|ICR-Mc [Moraxella catarrhalis BC1]
ATGTCCCTTAAACACAACCAAACCCACAACACCACTTTTACCAAATTTTTAAAGTCCAACAGCTTTTGGTCTAAGGGCTTTTGGTCTAAC
CGCCATCACCGCACCAAAGATTTAAAAGGGTTAGATGCTTATCTGTTTATGGCAATTGTGGCGATATTTTTGACCACAACTGCCAATGTG
ACATTTTTTCAACAAGTCATGTCAGTATACCCATTGGCAAATTACGCACCTTTTATCGCTTCATTGGCGGTGGTCTTAACAGGCGTTTTG
TTGCTCTTATTGGTGTTGCTTGGCTATCGGCATACCTTAAAGACGGTGGCAATTTGTTTTATTTTAATCGCTGCTTTTGCTGGTCATTTT
ACCGACACCTATGGCACTGTCTACGACACCACCATGCTACAAAATGCCTTACAAACTGACACGGCAGAAACCAAAGATTTATTAAGCATG
AAGCTTTTAATCCGTGTTGTGTTGTTGGCTGGTTTGCCCATCTGTTGGATTATTGGGCAGCCATTGTCATTTGGCACACTCAAAGCAAGT
TTAATGAAGCGGCTGGTTACCTATCTTGTGGCTTTGGCATTGGTTGGCTTGCCCATTTTGGCATTTAGCAGTCAATACGCCAGTTTTTTT
AGGGAACATAAACCGTTGCGATTTTTTACCAATCCTGTAACGGTGATGTATTCAGCAGGCAAACTTGCCAATATGAGTTATAAAAACGCC
ACCAAACCCACCGAAACCATCATGCACGCCAATGATGCCATACAAAAAACCACCGCTTCCACTCGCAAGCCCAGATTGGTGGTGATGGTG
GTGGGTGAGACGGCCCGTGCTGACCATGCGTCTTTTAATGGTTATCAGCGAGCCACTTTCCCTCATATGGACAAACTCATTGGCTTAGGG
CAAGTGCATAATTTTGGTAATGTCACTTCTTGTGGCACATCAACGGCATATTCTGTCCCATGTATGTTCAGTTATTTGGGAGCAGAAAAA
TACGATGTTGATACCGCCGATTACCATGAAAATGTCATTGACACCTTAGACCGCTTGGGTGTGGCGATATTGTGGCGAGATAATAACTCT
GATTCAAAAGGCGTGATGAATCGCCTGCCTGCCAAACAGTATCAAGACTACAAAAACAGCCCCCTTCAAGGTGGCAATAACACCATTTGC
CACACCAACCCTTATGATGAATGCCGTGATGTGGGCATGTTGGTGGATTTAGATGACCATGTCAAGGCTCATGCCAATCAAGACATATTA
ATAGTGTTGCATCAAATGGGCAACCATGGCCCTGCTTATTATAAACGCTATGACGATGAATTTGCTCAGTTTTTGCCTGTTTGTACAAGT
AGCGAGTTGGCAGAATGTGAGCGACAAACGGTCATTAATGCTTATGACAATGCGTTATTGGCGACTGATGACTTTTTAAAACAAACCATC
GATTGGTTGGCAGCACAAACACACGCTGACACCGCCATGTTATATTTAAGCGACCATGGTGAAAGCTTAGGAGAAAAAGGCGTTTATTTA
CATGGCATGCCTAAGGCGTTTGCCCCAAAAGAACAACTGAGCATTCCTGCGTTACTTTGGTTGGGAGCAGACACTCCATTTGCAGTGGCA
AATTCGCCAACGGCTGGCTTTAGCCACGATGCCATCACCCCGACACTGCTCAACTTATTTGATGTCAGCACACAAGCCACGGCAGATAAA
ACAGCATTTGTTAATCCTTTGGATTGA