Accession | ARO:3004585 |
Definition | KpnEF resembles EbrAB from E. coli. Mutation in KpnEF resulted in increased susceptibility to cefepime, ceftriaxon, colistin, erythromycin, rifampin, tetracycline, and streptomycin as well as enhanced sensitivity toward sodium dodecyl sulfate, deoxycholate, dyes, benzalkonium chloride, chlorhexidine, and triclosan. |
AMR Gene Family | small multidrug resistance (SMR) antibiotic efflux pump |
Drug Class | peptide antibiotic, disinfecting agents and antiseptics, rifamycin antibiotic, cephalosporin, aminoglycoside antibiotic, macrolide antibiotic, tetracycline antibiotic |
Resistance Mechanism | antibiotic efflux |
Efflux Component | efflux pump complex or subunit conferring antibiotic resistance |
Classification | 18 ontology terms | Show + process or component of antibiotic biology or chemistry + antibiotic molecule + peptide antibiotic [Drug Class] + mechanism of antibiotic resistance + beta-lactam antibiotic + lipopeptide antibiotic + cephem + polymyxin antibiotic + determinant of antibiotic resistance + antibiotic efflux [Resistance Mechanism] + disinfecting agents and antiseptics [Drug Class] + colistin + rifamycin antibiotic [Drug Class] + cephalosporin [Drug Class] + aminoglycoside antibiotic [Drug Class] + macrolide antibiotic [Drug Class] + tetracycline antibiotic [Drug Class] + efflux pump complex or subunit conferring antibiotic resistance [Efflux Component] |
Parent Term(s) | 12 ontology terms | Show + confers_resistance_to_antibiotic streptomycin [Antibiotic] + confers_resistance_to_antibiotic colistin A [Antibiotic] + confers_resistance_to_antibiotic colistin B [Antibiotic] + confers_resistance_to_antibiotic cefepime [Antibiotic] + confers_resistance_to_antibiotic ceftriaxone [Antibiotic] + confers_resistance_to_antibiotic erythromycin [Antibiotic] + confers_resistance_to_antibiotic rifampin [Antibiotic] + confers_resistance_to_antibiotic tetracycline [Antibiotic] + confers_resistance_to_antibiotic benzalkonium chloride [Antibiotic] + confers_resistance_to_antibiotic chlorhexidine [Antibiotic] + confers_resistance_to_antibiotic triclosan [Antibiotic] + small multidrug resistance (SMR) antibiotic efflux pump [AMR Gene Family] |
Sub-Term(s) | 2 ontology terms | Show |
Publications | Srinivasan VB, et al. 2013. Antimicrob. Agents Chemother. 57(9):4449-62 KpnEF, a new member of the Klebsiella pneumoniae cell envelope stress response regulon, is an SMR-type efflux pump involved in broad-spectrum antimicrobial resistance. (PMID 23836167) |