cefepime [Antibiotic]

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Accession ARO:0000059
Synonym(s)Maxipime Axepim Cefepimum FEP Cefepima
DefinitionCefepime (INN) is a fourth-generation cephalosporin antibiotic developed in 1994. It contains an aminothiazolyl group that decreases its affinity with beta-lactamases. Cefepime shows high binding affinity with penicillin-binding proteins and has an extended spectrum of activity against Gram-positive and Gram-negative bacteria, with greater activity against both Gram-negative and Gram-positive organisms than third-generation agents.
Drug Classcephalosporin
Classification4 ontology terms | Show
Parent Term(s)1 ontology terms | Show
+ cephalosporin [Drug Class]
18 ontology terms | Show
+ beta-lactam sensitive penicillin-binding protein targeted_by_antibiotic
+ Acinetobacter baumannii ampC beta-lactamase confers_resistance_to_antibiotic
+ AxyXY-OprZ confers_resistance_to_antibiotic
+ Klebsiella pneumoniae KpnEF confers_resistance_to_antibiotic
+ Escherichia coli ompF with mutation conferring resistance to beta-lactam antibiotics confers_resistance_to_antibiotic
+ SCO-1 confers_resistance_to_antibiotic
+ LAP-1 confers_resistance_to_antibiotic
+ LAP-2 confers_resistance_to_antibiotic
+ Klebsiella aerogenes Omp36 confers_resistance_to_antibiotic
+ Klebsiella pneumoniae OmpK35 confers_resistance_to_antibiotic
+ KPC-123 confers_resistance_to_antibiotic
+ VIM-63 confers_resistance_to_antibiotic
+ LAQ-1 confers_resistance_to_antibiotic
+ ACC-1 confers_resistance_to_antibiotic
+ cefepime-cloxacillin [Antibiotic] has_part
+ cefepime-taniborbactam [Antibiotic+Adjuvant] has_part
+ cefepime-tazobactam [Antibiotic+Adjuvant] has_part
+ cefepime-enmetazobactam [Antibiotic+Adjuvant] has_part

Grassi GG and Grassi C. 1993. J Antimicrob Chemother 32(SUPPL B): 87-94. Cefepime: overview of activity in vitro and in vivo. (PMID 8150771)