| Accession | ARO:0000059 |
| Synonym(s) | Maxipime Axepim Cefepimum FEP Cefepima |
| Definition | Cefepime (INN) is a fourth-generation cephalosporin antibiotic developed in 1994. It contains an aminothiazolyl group that decreases its affinity with beta-lactamases. Cefepime shows high binding affinity with penicillin-binding proteins and has an extended spectrum of activity against Gram-positive and Gram-negative bacteria, with greater activity against both Gram-negative and Gram-positive organisms than third-generation agents. |
| Drug Class | cephalosporin |
| Classification | 4 ontology terms | Show |
| Parent Term(s) | 1 ontology terms | Show + cephalosporin [Drug Class] |
| Sub-Term(s) | 18 ontology terms | Show + beta-lactam sensitive penicillin-binding protein targeted_by_antibiotic + Acinetobacter baumannii ampC beta-lactamase confers_resistance_to_antibiotic + AxyXY-OprZ confers_resistance_to_antibiotic + Klebsiella pneumoniae KpnEF confers_resistance_to_antibiotic + Escherichia coli ompF with mutation conferring resistance to beta-lactam antibiotics confers_resistance_to_antibiotic + SCO-1 confers_resistance_to_antibiotic + LAP-1 confers_resistance_to_antibiotic + LAP-2 confers_resistance_to_antibiotic + Klebsiella aerogenes Omp36 confers_resistance_to_antibiotic + Klebsiella pneumoniae OmpK35 confers_resistance_to_antibiotic + KPC-123 confers_resistance_to_antibiotic + VIM-63 confers_resistance_to_antibiotic + LAQ-1 confers_resistance_to_antibiotic + ACC-1 confers_resistance_to_antibiotic + cefepime-cloxacillin [Antibiotic] has_part + cefepime-taniborbactam [Antibiotic+Adjuvant] has_part + cefepime-tazobactam [Antibiotic+Adjuvant] has_part + cefepime-enmetazobactam [Antibiotic+Adjuvant] has_part |
| Publications | Grassi GG and Grassi C. 1993. J Antimicrob Chemother 32(SUPPL B): 87-94. Cefepime: overview of activity in vitro and in vivo. (PMID 8150771) |
