| Accession | ARO:3004580 |
| Synonym(s) | A6T8S5 |
| CARD Short Name | Kpne_KpnE |
| Definition | KpnE subunit of KpnEF resembles EbrAB from E. coli. Mutation in KpnEF resulted in increased susceptibility to cefepime, ceftriaxon, colistin, erythromycin, rifampin, tetracycline, and streptomycin as well as enhanced sensitivity toward sodium dodecyl sulfate, deoxycholate, dyes, benzalkonium chloride, chlorhexidine, and triclosan. |
| AMR Gene Family | small multidrug resistance (SMR) antibiotic efflux pump |
| Drug Class | peptide antibiotic, tetracycline antibiotic, rifamycin antibiotic, disinfecting agents and antiseptics, cephalosporin, aminoglycoside antibiotic, macrolide antibiotic |
| Resistance Mechanism | antibiotic efflux |
| Efflux Component | efflux pump complex or subunit conferring antibiotic resistance |
| Resistomes with Perfect Matches | Klebsiella aerogenesg, Klebsiella pneumoniaeg+wgs |
| Resistomes with Sequence Variants | Citrobacter amalonaticusg+wgs, Citrobacter freundiig+wgs, Citrobacter koserig+wgs, Citrobacter portucalensisg+wgs, Citrobacter werkmaniig+wgs, Citrobacter youngaeg+wgs, Cronobacter condimentig+wgs, Cronobacter dublinensisg+wgs, Cronobacter malonaticusg+wgs, Cronobacter sakazakiig+wgs, Cronobacter turicensiswgs, Cronobacter universalisg+wgs, Enterobacter asburiaeg+wgs, Enterobacter cancerogenusg+wgs, Enterobacter chengduensisg+wgs, Enterobacter cloacaeg+wgs, Enterobacter hormaecheig+wgs, Enterobacter kobeig+wgs, Enterobacter roggenkampiig+wgs, Escherichia albertiig+wgs, Escherichia colig+p+wgs, Escherichia marmotaeg+wgs, Klebsiella aerogenesg+wgs, Klebsiella huaxiensisg+wgs, Klebsiella michiganensisg+wgs, Klebsiella oxytocag+wgs, Klebsiella pneumoniaeg+p+wgs, Klebsiella quasipneumoniaeg+wgs, Kosakonia arachidisg+wgs, Leclercia adecarboxylatag+wgs, Pseudomonas aeruginosawgs, Raoultella planticolag+wgs, Salmonella bongorig+wgs, Salmonella entericag+wgs, Shigella boydiig+wgs, Shigella dysenteriaeg+wgs, Shigella flexnerig+wgs, Shigella sonneig+wgs |
| Classification | 30 ontology terms | Show + process or component of antibiotic biology or chemistry + antibiotic molecule + peptide antibiotic [Drug Class] + beta-lactam antibiotic + lipopeptide antibiotic + mechanism of antibiotic resistance + cephem + antibiotic efflux [Resistance Mechanism] + polymyxin antibiotic + determinant of antibiotic resistance + tetracycline antibiotic [Drug Class] + rifamycin antibiotic [Drug Class] + disinfecting agents and antiseptics [Drug Class] + efflux pump complex or subunit conferring antibiotic resistance [Efflux Component] + colistin + cephalosporin [Drug Class] + aminoglycoside antibiotic [Drug Class] + macrolide antibiotic [Drug Class] + cefepime [Antibiotic] + chlorhexidine [Antibiotic] + tetracycline [Antibiotic] + benzalkonium chloride [Antibiotic] + triclosan [Antibiotic] + colistin A [Antibiotic] + streptomycin [Antibiotic] + erythromycin [Antibiotic] + rifampin [Antibiotic] + colistin B [Antibiotic] + ceftriaxone [Antibiotic] + small multidrug resistance (SMR) antibiotic efflux pump [AMR Gene Family] |
| Parent Term(s) | 3 ontology terms | Show + confers_resistance_to_drug_class cephalosporin [Drug Class] + part_of Klebsiella pneumoniae KpnEF + subunit of efflux pump conferring antibiotic resistance |
| Publications | Srinivasan VB, et al. 2013. Antimicrob. Agents Chemother. 57(9):4449-62 KpnEF, a new member of the Klebsiella pneumoniae cell envelope stress response regulon, is an SMR-type efflux pump involved in broad-spectrum antimicrobial resistance. (PMID 23836167) |
Prevalence of Klebsiella pneumoniae KpnE among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 413 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).
| Species | NCBI Chromosome | NCBI Plasmid | NCBI WGS | NCBI GI |
|---|---|---|---|---|
| Citrobacter amalonaticus | 100% | 0% | 89.09% | 0% |
| Citrobacter freundii | 100% | 0% | 50.48% | 0% |
| Citrobacter koseri | 100% | 0% | 49.55% | 0% |
| Citrobacter portucalensis | 100% | 0% | 61.26% | 0% |
| Citrobacter werkmanii | 100% | 0% | 61.54% | 0% |
| Citrobacter youngae | 100% | 0% | 100% | 0% |
| Cronobacter condimenti | 100% | 0% | 100% | 0% |
| Cronobacter dublinensis | 100% | 0% | 100% | 0% |
| Cronobacter malonaticus | 100% | 0% | 85.45% | 0% |
| Cronobacter sakazakii | 100% | 0% | 91.7% | 0% |
| Cronobacter turicensis | 0% | 0% | 83.33% | 0% |
| Cronobacter universalis | 100% | 0% | 100% | 0% |
| Enterobacter asburiae | 100% | 0% | 70.36% | 0% |
| Enterobacter cancerogenus | 100% | 0% | 100% | 0% |
| Enterobacter chengduensis | 100% | 0% | 84% | 0% |
| Enterobacter cloacae | 100% | 0% | 73.48% | 0% |
| Enterobacter hormaechei | 99.28% | 0% | 67.03% | 0% |
| Enterobacter kobei | 100% | 0% | 68.56% | 0% |
| Enterobacter roggenkampii | 93.02% | 0% | 61.51% | 0% |
| Escherichia albertii | 100% | 0% | 62.58% | 0% |
| Escherichia coli | 67.63% | 0.03% | 61.56% | 0% |
| Escherichia marmotae | 100% | 0% | 70.83% | 0% |
| Klebsiella aerogenes | 100% | 0% | 79.94% | 0% |
| Klebsiella huaxiensis | 100% | 0% | 66.67% | 0% |
| Klebsiella michiganensis | 98.39% | 0% | 69.41% | 0% |
| Klebsiella oxytoca | 100% | 0% | 75.21% | 0% |
| Klebsiella pneumoniae | 99.17% | 0.01% | 57.14% | 0% |
| Klebsiella quasipneumoniae | 100% | 0% | 73.55% | 0% |
| Kosakonia arachidis | 100% | 0% | 100% | 0% |
| Leclercia adecarboxylata | 85.71% | 0% | 60.47% | 0% |
| Pseudomonas aeruginosa | 0% | 0% | 0.01% | 0% |
| Raoultella planticola | 100% | 0% | 94.87% | 0% |
| Salmonella bongori | 100% | 0% | 94.74% | 0% |
| Salmonella enterica | 95.52% | 0% | 81% | 0% |
| Shigella boydii | 100% | 0% | 98.89% | 0% |
| Shigella dysenteriae | 100% | 0% | 86.67% | 0% |
| Shigella flexneri | 100% | 0% | 82.14% | 0% |
| Shigella sonnei | 97.56% | 0% | 95.11% | 0% |
Model Type: protein homolog model
Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.
Bit-score Cut-off (blastP): 150