triclosan [Drug Class]

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Accession ARO:3000870
DefinitionTriclosan is a common antibacterial agent added to many consumer products as a biocide. It is an inhibitor of fatty acid biosynthesis by blocking enoyl-carrier protein reductase (FabI).
Classification2 ontology terms | Show
Parent Term(s)1 ontology terms | Show
Sub-Term(s)
11 ontology terms | Show
+ antibiotic sensitive enoyl-acyl carrier reductase targeted_by
+ MexJK-OpmH confers_resistance_to_antibiotic
+ determinant of triclosan resistance confers_resistance_to_antibiotic
+ TriABC-OpmH confers_resistance_to_antibiotic
+ Escherichia coli fabG mutations conferring resistance to triclosan confers_resistance_to_antibiotic
+ AcrAB-TolC confers_resistance_to_antibiotic
+ antibiotic resistant fabI [AMR Gene Family] confers_resistance_to_drug_class
+ antibiotic resistance fabG [AMR Gene Family] confers_resistance_to_drug_class
+ abeM confers_resistance_to_drug_class
+ triclosan resistant gyrA [AMR Gene Family] confers_resistance_to_drug_class
+ resistance-nodulation-cell division (RND) antibiotic efflux pump [AMR Gene Family] confers_resistance_to_drug_class
Publications

Priyadarshi A, et al. 2009. Proteins 78(2): 480-486. Structural insights into Staphylococcus aureus enoyl-ACP reductase (FabI), in complex with NADP and triclosan. (PMID 19768684)

Heath RJ, et al. 1999. J Biol Chem 274(16): 11110-11114. Mechanism of triclosan inhibition of bacterial fatty acid synthesis. (PMID 10196195)