triclosan [Antibiotic]

Download Sequences


Ontology CARD's Antibiotic Resistance Ontology
Accession ARO:3000870
DefinitionTriclosan is a common antibacterial agent added to many consumer products as a biocide. It is an inhibitor of fatty acid biosynthesis by blocking enoyl-carrier protein reductase (FabI).
SMILESOc1cc(Cl)ccc1Oc1ccc(Cl)cc1Cl
PubChem5564
ChEBI164200
CAS3380-34-5
ChEMBLCHEMBL849
Drug Classdisinfecting agents and antiseptics
Classification2 ontology terms | Show
Parent Term(s)1 ontology terms | Show
Sub-Term(s)
11 ontology terms | Show
+ MexJK-OpmH confers_resistance_to_antibiotic
+ TriABC-OpmH confers_resistance_to_antibiotic
+ Escherichia coli fabG mutations conferring resistance to triclosan confers_resistance_to_antibiotic
+ AcrAB-TolC confers_resistance_to_antibiotic
+ Escherichia coli fabI mutations conferring resistance to isoniazid and triclosan confers_resistance_to_antibiotic
+ abeM confers_resistance_to_antibiotic
+ Escherichia coli gyrA with mutation conferring resistance to triclosan confers_resistance_to_antibiotic
+ Salmonella enterica gyrA with mutation conferring resistance to triclosan confers_resistance_to_antibiotic
+ Klebsiella pneumoniae KpnEF confers_resistance_to_antibiotic
+ MexJK confers_resistance_to_antibiotic
+ antibiotic sensitive enoyl-acyl carrier reductase targeted_by_antibiotic
Publications

Priyadarshi A, et al. 2009. Proteins 78(2): 480-486. Structural insights into Staphylococcus aureus enoyl-ACP reductase (FabI), in complex with NADP and triclosan. (PMID 19768684)

Heath RJ, et al. 1999. J Biol Chem 274(16): 11110-11114. Mechanism of triclosan inhibition of bacterial fatty acid synthesis. (PMID 10196195)

Curator Acknowledgements
Curator Description Most Recent Edit