Accession | ARO:3000870 |
Definition | Triclosan is a common antibacterial agent added to many consumer products as a biocide. It is an inhibitor of fatty acid biosynthesis by blocking enoyl-carrier protein reductase (FabI). |
Classification | 2 ontology terms | Show |
Parent Term(s) | 1 ontology terms | Show |
Sub-Term(s) | 9 ontology terms | Show + antibiotic sensitive enoyl-acyl carrier reductase targeted_by + MexJK-OpmH confers_resistance_to_antibiotic + TriABC-OpmH confers_resistance_to_antibiotic + Escherichia coli fabG mutations conferring resistance to triclosan confers_resistance_to_antibiotic + AcrAB-TolC confers_resistance_to_antibiotic + antibiotic resistant fabI [AMR Gene Family] confers_resistance_to_drug_class + antibiotic resistant fabG [AMR Gene Family] confers_resistance_to_drug_class + abeM confers_resistance_to_drug_class + triclosan resistant gyrA [AMR Gene Family] confers_resistance_to_drug_class |
Publications | Priyadarshi A, et al. 2009. Proteins 78(2): 480-486. Structural insights into Staphylococcus aureus enoyl-ACP reductase (FabI), in complex with NADP and triclosan. (PMID 19768684) Heath RJ, et al. 1999. J Biol Chem 274(16): 11110-11114. Mechanism of triclosan inhibition of bacterial fatty acid synthesis. (PMID 10196195) |