Salmonella enterica gyrA with mutation conferring resistance to triclosan

Accession ARO:3004334
CARD Short NameSent_gyrA_TRC
DefinitionPoint mutations in Salmonella enterica serovar Typhimurium which have been shown to increase the minimum inhibitory concentration of the antibiotic triclosan. It is hypothesized that decreased susceptibility to triclosan in Salmonella gyrA mutants occurs indirectly due to alterations in the stress response pathways.
AMR Gene Familytriclosan resistant gyrA
Drug Classdisinfecting agents and antiseptics
Resistance Mechanismantibiotic target alteration
Resistomes with Sequence VariantsCitrobacter freundiig+wgs, Enterobacter asburiaeg, Enterobacter cloacaewgs, Enterobacter hormaecheiwgs, Enterobacter kobeiwgs, Klebsiella aerogenesg+wgs, Klebsiella oxytocag+wgs, Klebsiella pneumoniaeg+wgs, Klebsiella quasipneumoniaeg, Salmonella entericag+wgs, Serratia liquefacienswgs
Classification10 ontology terms | Show
Parent Term(s)2 ontology terms | Show
+ triclosan resistant gyrA [AMR Gene Family]
+ confers_resistance_to_antibiotic triclosan [Antibiotic]
Publications

Webber MA, et al. 2017. J. Antimicrob. Chemother. 72(10):2755-2763 Quinolone-resistant gyrase mutants demonstrate decreased susceptibility to triclosan. (PMID 29091182)

Resistomes

Prevalence of Salmonella enterica gyrA with mutation conferring resistance to triclosan among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 413 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).

Prevalence: protein variant model (view sequences)

SpeciesNCBI ChromosomeNCBI PlasmidNCBI WGSNCBI GI
Citrobacter freundii0.82%0%0.19%0%
Enterobacter asburiae3.23%0%0%0%
Enterobacter cloacae0%0%0.32%0%
Enterobacter hormaechei0%0%0.47%0%
Enterobacter kobei0%0%0.87%0%
Klebsiella aerogenes2%0%0.56%0%
Klebsiella oxytoca2.56%0%0.42%0%
Klebsiella pneumoniae20.53%0%6.17%0%
Klebsiella quasipneumoniae0.84%0%0%0%
Salmonella enterica1.32%0%0.94%0%
Serratia liquefaciens0%0%1.59%0%
Show Perfect Only


Detection Models

Model Type: protein variant model

Model Definition: Protein Variant Models (PVM) perform a similar search as Protein Homolog Models (PHM), i.e. detect protein sequences based on their similarity to a curated reference sequence, but secondarily screen query sequences for curated sets of mutations to differentiate them from antibiotic susceptible wild-type alleles. PVMs are designed to detect AMR acquired via mutation of house-keeping genes or antibiotic targets, e.g. a mutated gyrase resistant to aminocoumarin antibiotics. PVMs include a protein reference sequence (often from antibiotic susceptible wild-type alleles), a curated bit-score cut-off, and mapped resistance variants. Mapped resistance variants may include any or all of single point mutations, insertions, or deletions curated from the scientific literature. A Strict RGI match has a BLASTP bit-score above the curated BLASTP cutoff value and contains at least one curated mutation from amongst the mapped resistance variants, while a Loose RGI match has a bit-score less than the curated BLASTP bit-score cut-off but still contains at least one curated mutation from amongst the mapped resistance variants.

Bit-score Cut-off (blastP): 1500

Legend:

  • discovered in clinical, agricultural, or environmental isolates

  • discovered via laboratory selection experiments

  • ReSeqTB https://platform.reseqtb.org

Published Variants:

PMID: 29091182S83F D87G

>gb|AAL21173.1|-|Salmonella enterica gyrA with mutation conferring resistance to triclosan [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2]
MSDLAREITPVNIEEELKSSYLDYAMSVIVGRALPDVRDGLKPVHRRVLYAMNVLGNDWN
KAYKKSARVVGDVIGKYHPHGDSAVYDTIVRMAQPFSLRYMLVDGQGNFGSIDGDSAAAM
RYTEIRLAKIAHELMADLEKETVDFVDNYDGTEKIPDVMPTKIPNLLVNGSSGIAVGMAT
NIPPHNLTEVINGCLAYIDNEDISIEGLMEHIPGPDFPTAAIINGRRGIEEAYRTGRGKV
YIRARAEVEADAKTGRETIIVHEIPYQVNKARLIEKIAELVKDKRVEGISALRDESDKDG
MRIVIEVKRDAVGEVVLNNLYSQTQLQVSFGINMVALHHGQPKIMNLKDIISAFVRHRRE
VVTRRTIFELRKARDRAHILEALAIALANIDPIIELIRRAPTPAEAKAALISRPWDLGNV
AAMLERAGDDAARPEWLEPEFGVRDGQYYLTEQQAQAILDLRLQKLTGLEHEKLLDEYKE
LLEQIAELLHILGSADRLMEVIREEMELIRDQFGDERRTEITANSADINIEDLISQEDVV
VTLSHQGYVKYQPLTDYEAQRRGGKGKSAARIKEEDFIDRLLVANTHDTILCFSSRGRLY
WMKVYQLPEASRGARGRPIVNLLPLEANERITAILPVREYEEGVNVFMATASGTVKKTAL
TEFSRPRSAGIIAVNLNDGDELIGVDLTSGSDEVMLFSAAGKVVRFKEDAVRAMGRTATG
VRGIKLAGDDKVVSLIIPRGEGAILTVTQNGYGKRTAADEYPTKSRATQGVISIKVTERN
GSVVGAVQVDDCDQIMMITDAGTLVRTRVSEISVVGRNTQGVILIRTAEDENVVGLQRVA
EPVDDEELDAIDGSVAEGDEDIAPEAESDDDVADDADE



>gb|AE006468.2|-|2373710-2376346|Salmonella enterica gyrA with mutation conferring resistance to triclosan [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2]
ATGAGCGACCTTGCGAGAGAAATTACACCGGTCAACATTGAGGAGGAGCTGAAGAGCTCCTATCTGGATTATGCGATGTCGGTCATTGTT
GGCCGTGCGCTGCCGGATGTCCGAGATGGCCTGAAGCCGGTACACCGTCGCGTACTTTACGCCATGAACGTATTGGGCAATGACTGGAAC
AAAGCCTATAAAAAATCTGCCCGTGTCGTTGGTGACGTAATCGGTAAATACCATCCCCACGGCGATTCCGCAGTGTATGACACCATCGTT
CGTATGGCGCAGCCATTCTCGCTGCGTTACATGCTGGTGGATGGTCAGGGTAACTTCGGTTCTATTGACGGCGACTCCGCGGCGGCAATG
CGTTATACGGAGATCCGTCTGGCGAAAATCGCCCACGAACTGATGGCCGATCTCGAAAAAGAGACGGTGGATTTCGTGGATAACTATGAC
GGTACGGAAAAAATTCCGGACGTCATGCCGACCAAAATTCCGAATCTGCTGGTGAACGGTTCTTCCGGTATCGCAGTAGGTATGGCGACG
AATATCCCGCCGCACAACCTGACGGAAGTGATTAACGGCTGCCTGGCGTATATCGACAACGAAGACATCAGCATTGAAGGGCTGATGGAA
CATATTCCGGGGCCGGACTTCCCGACCGCCGCGATCATCAACGGTCGTCGTGGTATCGAAGAAGCCTACCGCACCGGTCGTGGCAAAGTG
TACATTCGCGCCCGCGCGGAAGTTGAAGCTGACGCCAAAACGGGCCGTGAAACCATCATCGTCCATGAAATTCCCTATCAGGTGAACAAA
GCGCGCCTGATCGAGAAAATCGCCGAGCTGGTGAAAGATAAACGCGTGGAAGGCATCAGCGCGCTGCGTGACGAATCCGACAAAGACGGG
ATGCGCATCGTGATTGAAGTGAAACGCGATGCGGTGGGCGAGGTGGTGCTTAATAATCTCTACTCCCAGACCCAGCTACAGGTTTCCTTC
GGTATTAACATGGTGGCGCTGCATCACGGCCAGCCGAAGATCATGAACCTGAAAGATATCATTTCAGCGTTCGTGCGCCACCGCCGTGAA
GTGGTGACGCGTCGGACTATTTTTGAACTGCGTAAAGCCCGTGACCGTGCGCATATCCTTGAAGCTCTGGCGATTGCGCTGGCCAACATC
GACCCGATTATCGAACTGATTCGCCGCGCGCCAACGCCGGCGGAAGCAAAAGCGGCGCTGATTTCGCGTCCGTGGGATCTGGGCAACGTT
GCTGCGATGCTGGAGCGCGCTGGTGATGACGCCGCGCGTCCGGAATGGCTGGAGCCAGAATTTGGCGTGCGTGACGGTCAGTACTACCTG
ACTGAACAGCAGGCGCAGGCGATTCTGGATCTGCGTTTGCAGAAACTGACCGGCCTGGAGCATGAAAAACTGCTCGACGAATACAAAGAG
CTGCTGGAGCAGATTGCTGAATTGCTGCACATTCTGGGCAGCGCCGATCGCCTGATGGAAGTGATCCGCGAAGAGATGGAGTTAATTCGC
GATCAGTTCGGCGATGAGCGTCGTACCGAAATCACCGCCAACAGCGCCGATATTAATATCGAAGATCTGATTAGCCAGGAAGATGTTGTC
GTGACGCTGTCTCACCAGGGTTACGTCAAATATCAACCGCTGACAGATTACGAAGCGCAACGTCGTGGTGGGAAAGGTAAATCTGCCGCG
CGTATTAAAGAAGAAGACTTTATCGACCGCCTGCTGGTGGCTAACACCCATGACACCATCCTCTGCTTCTCCAGCCGGGGCCGTCTGTAC
TGGATGAAGGTCTATCAGCTGCCGGAAGCCAGCCGCGGCGCGCGCGGTCGTCCGATCGTCAACCTGCTGCCGCTGGAAGCCAACGAACGT
ATCACCGCGATTCTGCCGGTTCGTGAGTATGAAGAAGGCGTCAACGTCTTTATGGCGACCGCCAGCGGTACCGTGAAGAAAACGGCGCTG
ACCGAATTCAGCCGTCCGCGTTCCGCCGGTATTATCGCGGTGAACCTCAACGACGGCGACGAGCTGATTGGCGTTGACCTGACTTCTGGT
TCTGACGAAGTCATGCTGTTCTCGGCCGCGGGTAAAGTGGTGCGCTTCAAAGAAGACGCCGTCCGTGCGATGGGGCGTACCGCGACCGGT
GTGCGCGGTATTAAGCTGGCGGGAGACGATAAAGTCGTCTCTCTGATCATCCCACGCGGCGAAGGCGCTATTCTGACCGTAACGCAAAAC
GGCTACGGGAAGCGTACCGCAGCGGACGAGTACCCGACCAAGTCTCGTGCGACGCAGGGCGTTATCTCTATCAAAGTGACCGAGCGCAAC
GGTTCCGTTGTCGGTGCGGTACAGGTAGACGATTGCGACCAGATCATGATGATCACGGATGCCGGTACTCTGGTGCGTACCCGTGTGTCC
GAGATCAGCGTAGTGGGACGTAATACCCAGGGCGTTATCCTTATCCGCACGGCGGAAGATGAAAACGTGGTGGGTCTGCAACGCGTTGCT
GAACCGGTAGATGACGAAGAACTCGACGCTATCGACGGCAGCGTGGCGGAAGGGGATGAGGATATCGCCCCGGAAGCGGAAAGCGATGAC
GACGTTGCGGATGACGCTGACGAGTAA