triclosan resistant gyrA [AMR Gene Family]

Accession ARO:3004333
DefinitionDNA gyrase is responsible for DNA supercoiling and consists of two alpha and two beta subunits. Point mutations in gyrA have been shown to decrease susceptibility to the antibiotic triclosan. Although the mechanism is unclear, it is hypothesized that changes in supercoiling activity of mutant DNA gyrase proteins alters expression of stress response pathways thereby indirectly decreasing triclosan susceptibility. It has been shown that triclosan does not interact directly with gyrA.
Drug Classtriclosan
Resistance Mechanismantibiotic target alteration
Classification9 ontology terms | Show
Parent Term(s)2 ontology terms | Show
+ antibiotic resistant DNA topoisomerase subunit gyrA
+ confers_resistance_to_drug_class triclosan [Drug Class]
2 ontology terms | Show

Webber MA, et al. 2017. J. Antimicrob. Chemother. 72(10):2755-2763 Quinolone-resistant gyrase mutants demonstrate decreased susceptibility to triclosan. (PMID 29091182)