TriABC-OpmH

Accession ARO:3003678
DefinitionTriABC-OpmH is a triclosan-specific efflux pump expressed in the Gram-negative Pseudomonas aeruginosa. TriABC is the only P. aeruginosa resistance nodulation cell division (RND) pump which contains two membrane fusion proteins, TriA and TriB, and both are required for efflux pump function. TriABC associated with OpmH assemble a functional triclosan efflux pump.
AMR Gene Familyresistance-nodulation-cell division (RND) antibiotic efflux pump
Drug Classtriclosan
Resistance Mechanismantibiotic efflux
Efflux Componentefflux pump complex or subunit conferring antibiotic resistance
Classification7 ontology terms | Show
Parent Term(s)2 ontology terms | Show
+ resistance-nodulation-cell division (RND) antibiotic efflux pump [AMR Gene Family]
+ confers_resistance_to_antibiotic triclosan [Drug Class]
Sub-Term(s)
4 ontology terms | Show
+ TriA part_of
+ TriB part_of
+ TriC part_of
+ OpmH part_of
Publications

Mima T, et al. 2007. J Bacteriol 189(21): 7600-7609. Identification and characterization of TriABC-OpmH, a triclosan efflux pump of Pseudomonas aeruginosa requiring two membrane fusion proteins. (PMID 17720796)

Resistomes

Prevalence of TriABC-OpmH among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI for 82 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).

Prevalence: efflux pump system meta-model

SpeciesNCBI ChromosomeNCBI PlasmidNCBI WGS
No prevalence data


Detection Models

Model Name: TriABC-OpmH

Model Description: TriABC-OpmH is a triclosan-specific efflux pump expressed in the Gram-negative Pseudomonas aeruginosa. TriABC is the only P. aeruginosa resistance nodulation cell division (RND) pump which contains two membrane fusion proteins, TriA and TriB, and both are required for efflux pump function. TriABC associated with OpmH assemble a functional triclosan efflux pump.

TriATriBTriCOpmH