TriC

Accession ARO:3003681
CARD Short NameTriC
DefinitionTriC is a resistance nodulation cell division (RND) transporter that is a part of TriABC-OpmH, a triclosan-specific efflux protein.
AMR Gene Familyresistance-nodulation-cell division (RND) antibiotic efflux pump
Drug Classdisinfecting agents and antiseptics
Resistance Mechanismantibiotic efflux
Efflux Componentefflux pump complex or subunit conferring antibiotic resistance
Resistomes with Perfect MatchesPseudomonas aeruginosag+wgs
Resistomes with Sequence VariantsAcinetobacter baumanniiwgs, Acinetobacter pittiiwgs, Enterobacter hormaecheiwgs, Enterococcus hiraewgs, Klebsiella oxytocawgs, Klebsiella pneumoniaewgs, Listeria monocytogeneswgs, Pseudomonas aeruginosag+wgs, Pseudomonas fluorescensg, Stenotrophomonas maltophiliawgs, Vibrio vulnificuswgs
Classification9 ontology terms | Show
Parent Term(s)2 ontology terms | Show
Publications

Mima T, et al. 2007. J Bacteriol 189(21): 7600-7609. Identification and characterization of TriABC-OpmH, a triclosan efflux pump of Pseudomonas aeruginosa requiring two membrane fusion proteins. (PMID 17720796)

Resistomes

Prevalence of TriC among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 377 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).

Prevalence: protein homolog model (view sequences)

SpeciesNCBI ChromosomeNCBI PlasmidNCBI WGSNCBI GI
Acinetobacter baumannii0%0%0.07%0%
Acinetobacter pittii0%0%0.33%0%
Enterobacter hormaechei0%0%0.05%0%
Enterococcus hirae0%0%0.51%0%
Klebsiella oxytoca0%0%0.49%0%
Klebsiella pneumoniae0%0%0.03%0%
Listeria monocytogenes0%0%0.03%0%
Pseudomonas aeruginosa99.62%0%75.36%0%
Pseudomonas fluorescens2.86%0%0%0%
Stenotrophomonas maltophilia0%0%1.72%0%
Vibrio vulnificus0%0%0.4%0%
Show Perfect Only


Detection Models

Model Type: protein homolog model

Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.

Bit-score Cut-off (blastP): 1900


>gb|AAG03548.1|+|TriC [Pseudomonas aeruginosa PAO1]
MKGGFNLSDWALRHQSLVWYLMAVSLVMGVFSYLNLGREEDPSFAIKTMVIQTRWPGATVDDTLEQVTDRIEKKLEELDSLDYVKSYTRP
GESTVFVYLKDTTKAGDIPDIWYQVRKKISDIQGEFPQGIQGPGFNDEFGDVFGSVYAFTADGLDFRQLRDYVEKVRLDIRSVKDLGKVQ
MIGAQNEVIYLNFSTRKLAALGLDQRQVVQSLQAQNAVTPSGVVEAGPERISVRTSGNFRSEKDLQAVNLRVNDRFYRLSDLASISRDFV
DPPTSLFRYKGEPAIGLAVAMKEGGNILEFGEALNARMQEITGELPVGVGVHQVSNQAQVVKKAVGGFTRALFEAVVIVLIVSFVSLGLR
AGLVVACSIPLVLAMVFVFMEYTDITMQRVSLGALIIALGLLVDDAMITVEMMITRLELGDSLHDSATYAYTSTAFPMLTGTLVTVAGFV
PIGLNASSAGEYTFTLFAVIAVALLLSWIVAVLFAPVIAVHILPKTLKHKSEQKKGRIAERFDSLLHLAMRRRWTTIFLTALLFGVSLFL
MKFVQHQFFPSSDRPELLVDLNLPQNSSIHETRAVMDRLEATLKDDEDIDHWSAYVGEGAIRFYLPLDQQLQNNFYGQLVIVTKDLEARE
RVAARLRDRLRKDYVGISTYVQPLEMGPPVGRPIQYRVSGPQIDKVREYAMGLAGVLDGNPNIGDIVYDWNEPGKMLKIDIAQDKARQLG
LSSEDVAQIMNSVVTGSAVTQVRDDIYLVNVIGRAEDSERGSLETLESLQIVTPSGTSIPLKAFAKVSYELEQPLVWRRDRKPTITVKAS
LRGEIQPTDLVARLAPEVKRFADGLPANYRIEVGGTVEESGKAEGPIAKVVPLMLFLMATFLMIQLQSVQKLFLVASVAPLGLIGVVAAL
LPTGTPMGFVAILGILALIGIIIRNSVILVTQIDAFEKDGKTPWEAVLEATHHRTRPILLTAAAASLGMIPIAREVFWGPMAYAMIGGIV
AATLLTLIFLPALYVAWYRIPEPGR


>gb|AE004091.2|+|179522-182569|TriC [Pseudomonas aeruginosa PAO1]
ATGAAGGGCGGTTTCAACCTGTCGGACTGGGCCCTGCGCCACCAGTCCCTGGTCTGGTACCTGATGGCGGTATCGCTGGTGATGGGCGTG
TTCTCCTACCTCAACCTGGGGCGCGAGGAGGATCCCTCGTTCGCCATCAAGACCATGGTCATCCAGACCCGCTGGCCGGGCGCCACGGTG
GACGACACCCTGGAGCAGGTCACCGACCGCATCGAGAAGAAGCTCGAGGAGCTGGACTCGCTGGATTACGTGAAGAGCTACACGCGACCC
GGCGAATCGACGGTCTTCGTCTACCTCAAGGACACCACCAAGGCCGGCGACATCCCGGATATCTGGTACCAGGTGCGCAAGAAGATATCC
GACATCCAGGGCGAATTCCCCCAGGGCATCCAGGGACCGGGTTTCAACGACGAGTTCGGCGACGTGTTCGGCAGCGTCTACGCCTTCACC
GCCGATGGCCTGGACTTCCGCCAGCTGCGCGACTACGTGGAGAAGGTGCGCCTGGACATCCGCTCGGTGAAAGACCTGGGCAAGGTGCAG
ATGATCGGTGCGCAGAACGAGGTCATCTACCTCAACTTCTCTACCCGCAAGCTGGCCGCCCTCGGTCTCGACCAGCGCCAGGTCGTGCAG
AGCCTGCAGGCGCAGAACGCGGTGACCCCGTCCGGCGTGGTCGAGGCCGGCCCCGAGCGCATCTCGGTGCGCACCTCCGGCAACTTCCGT
TCGGAAAAGGACCTGCAGGCGGTCAACCTGCGGGTCAACGATCGTTTCTACCGGCTGTCCGACCTGGCCAGCATCAGCCGCGATTTCGTC
GACCCGCCGACCTCGCTGTTCCGCTACAAGGGCGAGCCGGCCATCGGCCTGGCGGTGGCGATGAAGGAGGGCGGCAATATCCTCGAGTTC
GGCGAGGCGCTCAATGCGCGCATGCAGGAGATCACCGGCGAACTGCCGGTTGGCGTCGGCGTGCACCAGGTGTCGAACCAGGCCCAGGTG
GTGAAGAAGGCGGTCGGCGGTTTCACCCGGGCGCTGTTCGAGGCGGTGGTGATCGTCCTCATCGTCAGCTTCGTCAGCCTCGGCCTGCGC
GCCGGGCTGGTGGTGGCCTGCTCGATCCCGCTGGTGCTGGCGATGGTCTTCGTGTTCATGGAATACACCGACATCACCATGCAGCGGGTT
TCCCTCGGCGCGCTGATCATCGCCCTCGGCCTGCTGGTGGACGATGCCATGATCACCGTGGAGATGATGATCACGCGCCTCGAACTGGGC
GACTCGCTACACGACTCGGCGACCTACGCCTACACCTCGACGGCCTTCCCGATGCTCACCGGGACCCTGGTGACGGTGGCCGGCTTCGTA
CCCATCGGGCTCAACGCCAGCTCCGCCGGCGAGTACACCTTCACCCTGTTCGCAGTGATCGCCGTGGCGCTGCTGCTGTCGTGGATCGTC
GCGGTGCTGTTCGCCCCGGTGATCGCCGTGCACATCCTGCCGAAGACTCTCAAGCACAAGTCGGAGCAGAAGAAGGGCCGCATTGCCGAG
CGTTTCGACAGCCTGCTGCACCTGGCGATGCGCCGGCGCTGGACGACCATCTTCCTCACCGCGCTGCTGTTCGGCGTGTCGCTGTTCCTG
ATGAAGTTCGTCCAGCACCAGTTCTTCCCGTCTTCCGACCGTCCGGAACTGCTGGTCGACCTCAACCTGCCGCAGAACAGCAGCATCCAC
GAGACCAGGGCGGTGATGGACCGCCTGGAAGCGACGCTGAAGGACGACGAGGACATCGACCACTGGAGCGCCTACGTCGGCGAAGGCGCG
ATCCGCTTCTACCTGCCGCTGGACCAGCAGTTGCAGAACAACTTCTATGGCCAGCTGGTGATCGTCACCAAGGACCTGGAGGCCCGCGAG
CGCGTCGCCGCACGCCTGCGCGATCGCTTGCGCAAGGACTACGTCGGCATCAGCACCTACGTGCAGCCGCTGGAGATGGGGCCGCCGGTG
GGACGGCCGATCCAGTACCGGGTCAGCGGACCGCAGATCGACAAGGTCCGCGAGTACGCCATGGGCCTGGCCGGCGTGCTCGACGGCAAC
CCGAACATCGGCGATATCGTCTACGACTGGAACGAGCCCGGGAAGATGCTCAAGATCGACATCGCCCAGGACAAGGCGCGCCAGCTCGGG
CTTTCCTCCGAGGACGTGGCGCAGATCATGAACAGCGTGGTGACCGGCAGCGCGGTGACCCAGGTGCGCGACGACATCTACCTGGTGAAC
GTCATCGGCCGCGCCGAGGATAGCGAGCGCGGCTCGCTGGAGACCCTGGAGAGCCTGCAGATCGTCACGCCCAGCGGCACCTCGATCCCG
CTCAAGGCGTTCGCCAAGGTCAGCTACGAGCTGGAGCAGCCGCTGGTGTGGCGCCGCGACCGCAAGCCGACGATCACGGTGAAGGCGTCG
CTGCGCGGCGAGATCCAGCCCACCGACCTGGTCGCCCGGCTGGCGCCGGAGGTCAAGCGCTTCGCCGACGGCCTGCCGGCGAACTACCGG
ATCGAAGTGGGCGGCACGGTGGAGGAGAGCGGCAAGGCCGAGGGCCCGATCGCCAAGGTGGTGCCGCTGATGCTGTTCCTCATGGCGACC
TTCCTGATGATCCAGTTGCAGAGCGTGCAGAAGCTATTCCTGGTGGCCAGCGTCGCGCCGCTGGGGCTGATCGGGGTGGTCGCGGCGTTG
CTGCCGACCGGCACGCCGATGGGCTTCGTGGCGATCCTCGGGATTCTCGCGCTGATCGGCATCATCATCCGCAACTCGGTGATCCTGGTG
ACCCAGATCGATGCCTTCGAGAAAGACGGCAAGACGCCCTGGGAAGCCGTGCTGGAAGCCACCCACCACCGCACCCGGCCGATCCTGCTG
ACGGCGGCGGCGGCCAGCCTGGGGATGATCCCCATCGCCCGCGAAGTGTTCTGGGGGCCGATGGCCTATGCGATGATCGGCGGCATCGTC
GCCGCCACGCTGCTCACGCTGATCTTCCTGCCGGCGCTGTACGTCGCCTGGTACCGGATTCCGGAACCGGGACGCTGA