resistance-nodulation-cell division (RND) antibiotic efflux pump [AMR Gene Family]

Accession ARO:0010004
Synonym(s)RND type drug efflux
DefinitionDirected pumping of antibiotic out of a cell to confer resistance. Resistance-nodulation-division (RND) proteins are found in both prokaryotic and eukaryotic cells and have diverse substrate specificities and physiological roles. However, there are relatively few RND transporters and they are secondary transporters, energized not by ATP binding/hydrolysis but by proton movement down the transmembrane electrochemical gradient.
Drug Classtetracycline antibiotic, macrolide antibiotic, penam, fluoroquinolone antibiotic, glycylcycline, aminocoumarin antibiotic, acridine dye, antibacterial free fatty acids, triclosan, carbapenem, diaminopyrimidine antibiotic, phenicol antibiotic, monobactam, aminoglycoside antibiotic
Resistance Mechanismantibiotic efflux
Efflux Componentefflux pump complex or subunit conferring antibiotic resistance
Classification8 ontology terms | Show
Parent Term(s)15 ontology terms | Show
+ efflux pump complex or subunit conferring antibiotic resistance [Efflux Component]
+ confers_resistance_to_drug_class macrolide antibiotic [Drug Class]
+ confers_resistance_to_drug_class penam [Drug Class]
+ confers_resistance_to_drug_class fluoroquinolone antibiotic [Drug Class]
+ confers_resistance_to_drug_class glycylcycline [Drug Class]
+ confers_resistance_to_drug_class tetracycline antibiotic [Drug Class]
+ confers_resistance_to_drug_class aminocoumarin antibiotic [Drug Class]
+ confers_resistance_to_drug_class acridine dye [Drug Class]
+ confers_resistance_to_drug_class antibacterial free fatty acids [Drug Class]
+ confers_resistance_to_drug_class triclosan [Drug Class]
+ confers_resistance_to_drug_class carbapenem [Drug Class]
+ confers_resistance_to_drug_class diaminopyrimidine antibiotic [Drug Class]
+ confers_resistance_to_drug_class phenicol antibiotic [Drug Class]
+ confers_resistance_to_drug_class monobactam [Drug Class]
+ confers_resistance_to_drug_class aminoglycoside antibiotic [Drug Class]
Sub-Term(s)
33 ontology terms | Show
Publications

Murakami S, et al. 2006. Nature 443(7108): 173-179. Crystal structures of a multidrug transporter reveal a functionally rotating mechanism. (PMID 16915237)

Eswaran J, et al. 2000. Curr Opin Struct Biol 14(6): 741-747. Three's company: component structures bring a closer view of tripartite drug efflux pumps. (PMID 15582398)

Blair JM and Piddock LJ. 2009. Curr Opin Microbiol 12(5): 512-519. Structure, function and inhibition of RND efflux pumps in Gram-negative bacteria: an update. (PMID 19664953)