resistance-nodulation-cell division (RND) antibiotic efflux pump [AMR Gene Family]

Accession ARO:0010004
Synonym(s)RND type drug efflux
DefinitionDirected pumping of antibiotic out of a cell to confer resistance. Resistance-nodulation-division (RND) proteins are found in both prokaryotic and eukaryotic cells and have diverse substrate specificities and physiological roles. However, there are relatively few RND transporters and they are secondary transporters, energized not by ATP binding/hydrolysis but by proton movement down the transmembrane electrochemical gradient.
Resistance Mechanismantibiotic efflux
Efflux Componentefflux pump complex or subunit conferring antibiotic resistance
Classification4 ontology terms | Show
Parent Term(s)1 ontology terms | Show
Sub-Term(s)
33 ontology terms | Show
Publications

Murakami S, et al. 2006. Nature 443(7108): 173-179. Crystal structures of a multidrug transporter reveal a functionally rotating mechanism. (PMID 16915237)

Eswaran J, et al. 2000. Curr Opin Struct Biol 14(6): 741-747. Three's company: component structures bring a closer view of tripartite drug efflux pumps. (PMID 15582398)

Blair JM and Piddock LJ. 2009. Curr Opin Microbiol 12(5): 512-519. Structure, function and inhibition of RND efflux pumps in Gram-negative bacteria: an update. (PMID 19664953)