Accession ARO:3002981
DefinitionAmrAB is an RND efflux system that impairs aminoglycoside accumulation in clinical Burkholderia vietnamiensis strains
AMR Gene Familyresistance-nodulation-cell division (RND) antibiotic efflux pump
Drug Classtetracycline antibiotic, antibacterial free fatty acids, phenicol antibiotic, diaminopyrimidine antibiotic, glycylcycline, aminocoumarin antibiotic, penam, monobactam, fluoroquinolone antibiotic, acridine dye, macrolide antibiotic, triclosan, carbapenem, aminoglycoside antibiotic
Resistance Mechanismantibiotic efflux
Efflux Componentefflux pump complex or subunit conferring antibiotic resistance
Classification22 ontology terms | Show
Parent Term(s)2 ontology terms | Show
+ confers_resistance_to_drug_class aminoglycoside antibiotic [Drug Class]
+ resistance-nodulation-cell division (RND) antibiotic efflux pump [AMR Gene Family]
3 ontology terms | Show
+ amrA part_of
+ amrB part_of
+ OprM part_of

Jassem AN, et al. 2014. Ann Clin Microbiol Antimicrob 13(1): 2. Investigation of aminoglycoside resistance inducing conditions and a putative AmrAB-OprM efflux system in Burkholderia vietnamiensis. (PMID 24393536)

Westbrock-Wadman S, et al. 1999. Antimicrob Agents Chemother 43(12): 2975-2983. Characterization of a Pseudomonas aeruginosa efflux pump contributing to aminoglycoside impermeability. (PMID 10582892)