Accession ARO:3002981
DefinitionAmrAB is an RND efflux system that impairs aminoglycoside accumulation in clinical Burkholderia vietnamiensis strains.
AMR Gene Familyresistance-nodulation-cell division (RND) antibiotic efflux pump
Drug Classaminoglycoside antibiotic, macrolide antibiotic
Resistance Mechanismantibiotic efflux
Efflux Componentefflux pump complex or subunit conferring antibiotic resistance
Classification8 ontology terms | Show
Parent Term(s)4 ontology terms | Show
+ resistance-nodulation-cell division (RND) antibiotic efflux pump [AMR Gene Family]
+ confers_resistance_to_drug_class aminoglycoside antibiotic [Drug Class]
+ confers_resistance_to_antibiotic tobramycin [Antibiotic]
+ confers_resistance_to_antibiotic azithromycin [Antibiotic]
3 ontology terms | Show
+ amrA part_of
+ amrB part_of
+ OprM part_of

Jassem AN, et al. 2014. Ann Clin Microbiol Antimicrob 13(1): 2. Investigation of aminoglycoside resistance inducing conditions and a putative AmrAB-OprM efflux system in Burkholderia vietnamiensis. (PMID 24393536)

Westbrock-Wadman S, et al. 1999. Antimicrob Agents Chemother 43(12): 2975-2983. Characterization of a Pseudomonas aeruginosa efflux pump contributing to aminoglycoside impermeability. (PMID 10582892)