| Accession | ARO:3000379 |
| Definition | OprM is an outer membrane factor protein found in Pseudomonas aeruginosa and Burkholderia vietnamiensis. It is part of the MexAB-OprM, MexVW-OprM, MexXY-OprM and the AmrAB-OprM complex. |
| AMR Gene Family | resistance-nodulation-cell division (RND) antibiotic efflux pump |
| Drug Class | peptide antibiotic, sulfonamide antibiotic, penam, diaminopyrimidine antibiotic, fluoroquinolone antibiotic, carbapenem, macrolide antibiotic, cephalosporin, tetracycline antibiotic, phenicol antibiotic, aminocoumarin antibiotic, monobactam, penem, acridine dye, aminoglycoside antibiotic, cephamycin |
| Resistance Mechanism | antibiotic efflux |
| Efflux Component | efflux pump complex or subunit conferring antibiotic resistance |
| Resistomes with Perfect Matches | Pseudomonas aeruginosag+wgs, Pseudomonas fluorescensg |
| Resistomes with Sequence Variants | Acinetobacter baumanniiwgs, Klebsiella pneumoniaewgs, Pseudomonas aeruginosag+wgs, Pseudomonas fluorescensg, Stenotrophomonas maltophiliawgs |
| Classification | 61 ontology terms | Show + process or component of antibiotic biology or chemistry + antibiotic molecule + peptide antibiotic [Drug Class] + mechanism of antibiotic resistance + lipopeptide antibiotic + beta-lactam antibiotic + resistance-modifying agents + polymyxin antibiotic + beta-lactamase inhibitor + sulfonamide antibiotic [Drug Class] + determinant of antibiotic resistance + cephem + penam [Drug Class] + antibiotic efflux [Resistance Mechanism] + diaminopyrimidine antibiotic [Drug Class] + antibiotic mixture + sulfamethoxazole [Antibiotic] + fluoroquinolone antibiotic [Drug Class] + carbapenem [Drug Class] + macrolide antibiotic [Drug Class] + clavulanic acid [Adjuvant] + cephalosporin [Drug Class] + efflux pump complex or subunit conferring antibiotic resistance [Efflux Component] + tetracycline antibiotic [Drug Class] + colistin + trimethoprim [Antibiotic] + phenicol antibiotic [Drug Class] + aminocoumarin antibiotic [Drug Class] + amoxicillin [Antibiotic] + monobactam [Drug Class] + meropenem [Antibiotic] + tetracycline [Antibiotic] + ciprofloxacin [Antibiotic] + colistin A [Antibiotic] + penem [Drug Class] + acridine dye [Drug Class] + aminoglycoside antibiotic [Drug Class] + cephamycin [Drug Class] + ceftazidime [Antibiotic] + colistin B [Antibiotic] + resistance-nodulation-cell division (RND) antibiotic efflux pump [AMR Gene Family] + azithromycin [Antibiotic] + ampicillin [Antibiotic] + ceftriaxone [Antibiotic] + amoxicillin-clavulanic acid [Antibiotic] + chloramphenicol [Antibiotic] + novobiocin [Antibiotic] + trimethoprim-sulfamethoxazole [Antibiotic] + erythromycin [Antibiotic] + aztreonam [Antibiotic] + panipenem [Antibiotic] + nalidixic acid [Antibiotic] + amikacin [Antibiotic] + gentamicin C [Antibiotic] + MexAB-OprM + tobramycin [Antibiotic] + ticarcillin [Antibiotic] + acriflavine [Antibiotic] + norfloxacin [Antibiotic] + ofloxacin [Antibiotic] + thiamphenicol [Antibiotic] |
| Parent Term(s) | 12 ontology terms | Show + part_of MexAB-OprM + subunit of efflux pump conferring antibiotic resistance + part_of MexXY-OprM + part_of AmrAB-OprM + part_of MexVW-OprM + part_of MexJK-OprM + part_of MexMN-OprM + part_of MexAB-OprM with prematurely terminated MexR conferring resistance to meropenem and ciprofloxacin + part_of MexAB-OprM with NalC mutations conferring resistance to aztreonam + part_of MexAB-OprM with NalD mutations conferring resistance to multiple antibiotics + part_of MexAB-OprM with CpxR regulator conferring resistance to ciprofloxacin, ceftazidime, and aztreonam + part_of MexAB-OprM with MexR mutations confers resistance to multiple antibiotics |
| Publications | Lambert O, et al. 2005. J Struct Biol 150(1): 50-57. Trimeric structure of OprN and OprM efflux proteins from Pseudomonas aeruginosa, by 2D electron crystallography. (PMID 15797729) Akama H, et al. 2005. Acta Crystallogr Sect F Struct Biol Cryst Commun 61(PT 1): 131-133. Preliminary crystallographic analysis of the antibiotic discharge outer membrane lipoprotein OprM of Pseudomonas aeruginosa with an exceptionally long unit cell and complex lattice structure. (PMID 16508113) Broutin I, et al. 2005. Acta Crystallogr Sect F Struct Biol Cryst Commun 61(PT 3): 315-318. Expression, purification, crystallization and preliminary X-ray studies of the outer membrane efflux proteins OprM and OprN from Pseudomonas aeruginosa. (PMID 16511029) |
Prevalence of OprM among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI for 88 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).
| Species | NCBI Chromosome | NCBI Plasmid | NCBI WGS |
|---|---|---|---|
| Acinetobacter baumannii | 0% | 0% | 0.02% |
| Enterobacter cloacae | 0% | 0% | 0% |
| Klebsiella pneumoniae | 0% | 0% | 0.01% |
| Pseudomonas aeruginosa | 100% | 0% | 99.09% |
| Pseudomonas fluorescens | 3.85% | 0% | 0% |
| Stenotrophomonas maltophilia | 0% | 0% | 0.53% |
Model Type: protein homolog model
Model Definition: The protein homolog model is an AMR detection model. Protein homolog models detect a protein sequence based on its similarity to a curated reference sequence. A protein homolog model has only one parameter: a curated BLASTP bitscore cutoff for determining the strength of a match. Protein homolog model matches to reference sequences are categorized on three criteria: perfect, strict and loose. A perfect match is 100% identical to the reference sequence along its entire length; a strict match is not identical but the bitscore of the matched sequence is greater than the curated BLASTP bitscore cutoff. Loose matches are other sequences with a match bitscore less than the curated BLASTP bitscore.
Bit-score Cut-off (blastP): 850
