| Accession | ARO:3005066 |
| Definition | parRS is a two-component sensor that mediates MexXY/OprM and porin OprD to confer resistance to polycationic antibiotics. It has multiple mechanisms of resistance such as LPS modification, efflux mediation and reduced porin pathway. |
| AMR Gene Family | Outer Membrane Porin (Opr), resistance-nodulation-cell division (RND) antibiotic efflux pump |
| Drug Class | aminoglycoside antibiotic, disinfecting agents and antiseptics, penem, phenicol antibiotic, tetracycline antibiotic, penam, cephamycin, cephalosporin, carbapenem, monobactam, fluoroquinolone antibiotic, macrolide antibiotic |
| Resistance Mechanism | reduced permeability to antibiotic, antibiotic efflux |
| Efflux Component | efflux pump complex or subunit conferring antibiotic resistance |
| Efflux Regulator | protein(s) and two-component regulatory system modulating antibiotic efflux |
| Classification | 39 ontology terms | Show + process or component of antibiotic biology or chemistry + antibiotic molecule + beta-lactam antibiotic + mechanism of antibiotic resistance + antibiotic mixture + cephem + reduced permeability to antibiotic [Resistance Mechanism] + determinant of antibiotic resistance + antibiotic efflux [Resistance Mechanism] + aminoglycoside antibiotic [Drug Class] + gentamicin [Antibiotic] + disinfecting agents and antiseptics [Drug Class] + penem [Drug Class] + phenicol antibiotic [Drug Class] + protein modulating permeability to antibiotic + efflux pump complex or subunit conferring antibiotic resistance [Efflux Component] + tetracycline antibiotic [Drug Class] + penam [Drug Class] + cephamycin [Drug Class] + cephalosporin [Drug Class] + carbapenem [Drug Class] + monobactam [Drug Class] + fluoroquinolone antibiotic [Drug Class] + macrolide antibiotic [Drug Class] + Outer Membrane Porin (Opr) [AMR Gene Family] + ofloxacin [Antibiotic] + norfloxacin [Antibiotic] + protein(s) and two-component regulatory system modulating antibiotic efflux [Efflux Regulator] + chloramphenicol [Antibiotic] + imipenem [Antibiotic] + resistance-nodulation-cell division (RND) antibiotic efflux pump [AMR Gene Family] + meropenem [Antibiotic] + tobramycin [Antibiotic] + tetracycline [Antibiotic] + acriflavine [Antibiotic] + ciprofloxacin [Antibiotic] + gentamicin C [Antibiotic] + amikacin [Antibiotic] + erythromycin [Antibiotic] |
| Parent Term(s) | 4 ontology terms | Show |
| Sub-Term(s) | 2 ontology terms | Show |
| Publications | Stover CK, et al. 2000. Nature 406(6799): 959-964. Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic pathogen. (PMID 10984043) Winsor GL, et al. 2004. Nucleic Acids Res 33(DATABASE ISSUE): D338-D343. Pseudomonas aeruginosa Genome Database and PseudoCAP: facilitating community-based, continually updated, genome annotation. (PMID 15608211) Winsor GL, et al. 2008. Nucleic Acids Res 37(DATABASE ISSUE): D483-D488. Pseudomonas Genome Database: facilitating user-friendly, comprehensive comparisons of microbial genomes. (PMID 18978025) Muller C, et al. 2011. Antimicrob. Agents Chemother. 55(3):1211-21 A two-component regulatory system interconnects resistance to polymyxins, aminoglycosides, fluoroquinolones, and β-lactams in Pseudomonas aeruginosa. (PMID 21149619) |