Accession ARO:3005066
DefinitionparRS is a two-component sensor that mediates MexXY/OprM and porin OprD to confer resistance to polycationic antibiotics. It has multiple mechanisms of resistance such as LPS modification, efflux mediation and reduced porin pathway.
AMR Gene FamilyOuter Membrane Porin (Opr), resistance-nodulation-cell division (RND) antibiotic efflux pump
Drug Classaminoglycoside antibiotic, fluoroquinolone antibiotic, carbapenem, macrolide antibiotic, disinfecting agents and antiseptics, penam, phenicol antibiotic, tetracycline antibiotic, cephamycin, penem, monobactam, cephalosporin
Resistance Mechanismantibiotic efflux, reduced permeability to antibiotic
Efflux Componentefflux pump complex or subunit conferring antibiotic resistance
Efflux Regulatorprotein(s) and two-component regulatory system modulating antibiotic efflux
Classification39 ontology terms | Show
Parent Term(s)4 ontology terms | Show
2 ontology terms | Show
+ ParS part_of
+ ParR part_of

Stover CK, et al. 2000. Nature 406(6799): 959-964. Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic pathogen. (PMID 10984043)

Winsor GL, et al. 2004. Nucleic Acids Res 33(DATABASE ISSUE): D338-D343. Pseudomonas aeruginosa Genome Database and PseudoCAP: facilitating community-based, continually updated, genome annotation. (PMID 15608211)

Winsor GL, et al. 2008. Nucleic Acids Res 37(DATABASE ISSUE): D483-D488. Pseudomonas Genome Database: facilitating user-friendly, comprehensive comparisons of microbial genomes. (PMID 18978025)

Muller C, et al. 2011. Antimicrob. Agents Chemother. 55(3):1211-21 A two-component regulatory system interconnects resistance to polymyxins, aminoglycosides, fluoroquinolones, and β-lactams in Pseudomonas aeruginosa. (PMID 21149619)