SmeDEF

Accession ARO:3003054
DefinitionSmeDEF is a multidrug resistance efflux pump that confers resistance to quinolones, tetracyclines, macrolides, chloramphenicol, and novobiocin in Stenotrophomonas maltophilia
AMR Gene Familyresistance-nodulation-cell division (RND) antibiotic efflux pump
Drug Classtetracycline antibiotic, monobactam, phenicol antibiotic, aminocoumarin antibiotic, fluoroquinolone antibiotic, glycylcycline, antibacterial free fatty acids, penam, aminoglycoside antibiotic, acridine dye, macrolide antibiotic, triclosan, diaminopyrimidine antibiotic, carbapenem
Resistance Mechanismantibiotic efflux
Efflux Componentefflux pump complex or subunit conferring antibiotic resistance
Classification22 ontology terms | Show
Parent Term(s)5 ontology terms | Show
+ resistance-nodulation-cell division (RND) antibiotic efflux pump [AMR Gene Family]
+ confers_resistance_to_antibiotic chloramphenicol [Antibiotic]
+ confers_resistance_to_drug_class macrolide antibiotic [Drug Class]
+ confers_resistance_to_antibiotic tetracycline [Antibiotic]
+ confers_resistance_to_drug_class fluoroquinolone antibiotic [Drug Class]
Sub-Term(s)
3 ontology terms | Show
+ smeD part_of
+ smeE part_of
+ smeF part_of
Publications

Zhang L, et al. 2001. Antimicrob Agents Chemother 45(12): 3497-3503. SmeDEF multidrug efflux pump contributes to intrinsic multidrug resistance in Stenotrophomonas maltophilia. (PMID 11709330)