smeF

Accession ARO:3003057
DefinitionsmeF is an outer membrane multidrug efflux protein of the smeDEF complex in Stenotrophomonas maltophilia
AMR Gene Familyresistance-nodulation-cell division (RND) antibiotic efflux pump
Drug Classphenicol antibiotic, tetracycline antibiotic, fluoroquinolone antibiotic, macrolide antibiotic
Resistance Mechanismantibiotic efflux
Efflux Componentefflux pump complex or subunit conferring antibiotic resistance
Classification13 ontology terms | Show
Parent Term(s)2 ontology terms | Show
Publications

Zhang L, et al. 2001. Antimicrob Agents Chemother 45(12): 3497-3503. SmeDEF multidrug efflux pump contributes to intrinsic multidrug resistance in Stenotrophomonas maltophilia. (PMID 11709330)

Resistomes

Prevalence of smeF among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI for 82 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).

Prevalence: protein homolog model (view sequences)

SpeciesNCBI ChromosomeNCBI PlasmidNCBI WGS
Stenotrophomonas maltophilia95.83%0%91.78%
Show Perfect Only


Detection Models

Model Type: protein homolog model

Model Definition: The protein homolog model is an AMR detection model. Protein homolog models detect a protein sequence based on its similarity to a curated reference sequence. A protein homolog model has only one parameter: a curated BLASTP bitscore cutoff for determining the strength of a match. Protein homolog model matches to reference sequences are categorized on three criteria: perfect, strict and loose. A perfect match is 100% identical to the reference sequence along its entire length; a strict match is not identical but the bitscore of the matched sequence is greater than the curated BLASTP bitscore cutoff. Loose matches are other sequences with a match bitscore less than the curated BLASTP bitscore.

Bit-score Cut-off (blastP): 890


>gb|CAC14596.1|+|smeF [Stenotrophomonas maltophilia]
MEVIPMKSASLFLSIAATLALAGCSTLAPKNTAVAPAIPAQWPAEAAQGEVADVAAVGWRDFFTDARLQQVIEQSLQNNRDLRVAVLNVE
RARGQYRVQRADRVPGVAVTGQMDRRGTDAGVTEQFSAGVGVAEFELDLFGRVRNLSEAALQQYFAVAANRRNAQLSLVAETATAWLTYG
ADAQRLKIADATLKTYEDSLRLAEARHERGGSSALELTQTRTLVETARTDAARLRGQLAQDRNALALLAGGQLDPALLPDSIEPQLLALA
PPPAGLPSDVLLQRPDIMAAEHQLLAANANIGAARAAFFPSISLTGSIGSGSSELSNLFDSGTRVWSFLPKITLPIFQGGKLRANLAIAN
ADRDIALAQYEKSIQVGFRETADALALNVSLDEQVSSQQRLVEAAEQANRLSQARYDAGLDSFVTLLDARRTAYNAQQTQLQAQLAQQAN
RITLYKVLGGGWHERG


>gb|AJ252200|+|4494-5894|smeF [Stenotrophomonas maltophilia]
ATGGAAGTGATCCCCATGAAAAGTGCATCCCTGTTCCTCTCCATTGCCGCCACGCTCGCGCTGGCCGGCTGCTCCACCCTGGCGCCGAAG
AACACCGCCGTCGCTCCGGCGATTCCTGCGCAGTGGCCGGCCGAGGCCGCGCAGGGCGAGGTGGCCGATGTCGCCGCCGTCGGCTGGCGC
GATTTCTTCACCGATGCGCGCCTGCAGCAGGTGATCGAGCAGTCGCTGCAGAACAACCGCGACCTGCGCGTGGCCGTGCTCAATGTCGAG
CGCGCGCGTGGCCAGTACCGCGTGCAGCGCGCCGATCGCGTGCCCGGCGTGGCCGTGACCGGCCAGATGGACCGCCGTGGTACCGATGCC
GGTGTCACCGAGCAGTTCAGCGCGGGCGTGGGTGTGGCCGAGTTCGAGCTGGACCTGTTCGGTCGCGTGCGCAACCTCAGCGAGGCGGCG
CTGCAGCAGTACTTCGCCGTGGCTGCCAACCGCCGCAACGCGCAGCTGAGCCTGGTGGCCGAGACCGCCACCGCGTGGCTGACCTATGGG
GCTGATGCGCAGCGGCTGAAGATCGCCGATGCCACGCTGAAGACCTACGAGGATTCGCTGCGCTTGGCCGAGGCCCGCCACGAACGCGGC
GGCAGTTCGGCGCTGGAGCTGACCCAGACCCGTACCTTGGTCGAGACCGCACGCACCGATGCCGCGCGCCTGCGCGGCCAGCTGGCCCAG
GACCGCAACGCACTGGCGCTGCTGGCCGGTGGCCAGCTCGATCCGGCACTGCTGCCGGACAGCATCGAACCGCAGCTGCTGGCGCTGGCC
CCGCCGCCGGCCGGCCTGCCCAGCGACGTGCTGCTGCAGCGCCCGGACATCATGGCCGCCGAACACCAGCTGCTGGCCGCCAATGCCAAC
ATCGGTGCGGCACGCGCAGCGTTCTTCCCGAGCATCTCGCTGACCGGCAGCATCGGCAGCGGCTCCAGCGAACTGTCCAACCTGTTCGAC
AGCGGCACCCGTGTGTGGAGCTTCCTGCCGAAGATCACCCTGCCGATCTTCCAGGGCGGCAAGCTGCGCGCCAACCTGGCCATCGCCAAC
GCGGATCGTGATATCGCACTGGCGCAGTACGAGAAGTCGATCCAGGTGGGATTCCGCGAAACGGCCGATGCGCTGGCGTTGAATGTCAGC
CTGGATGAGCAGGTGAGTTCACAGCAGCGCCTGGTGGAAGCGGCCGAACAGGCCAATCGCCTGTCGCAGGCACGCTACGACGCGGGGCTG
GACAGCTTTGTCACCCTGCTTGACGCGCGGCGTACCGCCTACAACGCGCAGCAGACCCAGCTGCAGGCGCAGTTGGCGCAGCAGGCCAAC
CGCATCACCCTGTACAAGGTGCTGGGCGGCGGCTGGCACGAGCGCGGGTAA