smeE

Accession ARO:3003056
CARD Short NamesmeE
DefinitionsmeE is the RND protein of the efflux complex smeDEF in Stenotrophomonas maltophilia.
AMR Gene Familyresistance-nodulation-cell division (RND) antibiotic efflux pump
Drug Classtetracycline antibiotic, phenicol antibiotic, fluoroquinolone antibiotic, macrolide antibiotic
Resistance Mechanismantibiotic efflux
Efflux Componentefflux pump complex or subunit conferring antibiotic resistance
Classification13 ontology terms | Show
Parent Term(s)2 ontology terms | Show
Publications

Zhang L, et al. 2001. Antimicrob Agents Chemother 45(12): 3497-3503. SmeDEF multidrug efflux pump contributes to intrinsic multidrug resistance in Stenotrophomonas maltophilia. (PMID 11709330)

Resistomes

Prevalence of smeE among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 413 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).

Prevalence: protein homolog model

SpeciesNCBI ChromosomeNCBI PlasmidNCBI WGSNCBI GI
No prevalence data


Detection Models

Model Type: protein homolog model

Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.

Bit-score Cut-off (blastP): 2070


>gb|CAC14595.1|+|smeE [Stenotrophomonas maltophilia]
MARFFIDRPIFAWVIAIIIMLAGGLALFKLPVSMYPNVAPPAVEISATYPGASAKVVEDSVTQIIEQNMKGLDGLIYFSSNSSSNGQATI
TLTFESGTNPDIAQVQVQNKLQLAMPLLPQEVQRQGINVAKSSSGFLNAIAFVSENGSMDANDIADYVGSNVVDRLSRVPGVGNIQVFGG
KYAMRIWLDPNKLHTYGLSVPEVTAAIKAQNAQVAIGQLGGAPSVKGQQLNATINAQSRLQTPEQFRNIIVRGAQDGAELRLGDVARVEL
GAESYDFVTRYNGQPASGLAVTLATGANALDTAAGVDAALEDMKGFFPAGLKAEIPYDTTPFVRVSIKGVVQTLIEAIVLVFVVMYLFLQ
NFRATLIPTIAVPVVLLGTFGVLAMLGFSVNMLTMFAMVLAIGLLVDDAIVVVENVERIMSEEGLSPLEATRKSMGQITGALVGIGLVLS
AVFVPMAFMSGSTGVIYRQFSATIVSAMALSVLVAIVLTPALCATMLKPLKKGEHHVAHRGLAGRFFNGFNRGFDRTSESYQRGVRGIIH
RPWRFMGIVAALFVLMGVLFVRLPSSFLPNEDQGVLMALVQAPVGATQERTLESIAALENHFLQNEKDAVDSVFSVQGFSFAGMGQNAGM
AFVKLKDWSERDADNGVMPITGRAMAALGQIKDAFIFAFPPPAIPELGTASGYTFFLKDNSGQGHEALVAARNQLLGLAAGSKKLANVRP
NGQEDTPQFRIDIDAAKATSLGLSIDQINGTLAAAWGSSYIDDFVDRGRVKRVFVQADQAFRMVPEDFDLWSVKNDKGEMVPFSAFATKH
WDYGSPRLERYNGVSAMEIQGEPAPGVASGDAMAEIEQLAKQLPAGFGIEWTAMSYQERQAGSQTPLLYTLSLMIVFLCLAAMYESWSVP
TAVLLAAPLGILGAVLANTFKGLERDIYFQVAMLTTVGLTSKNAILIVEFAKENLEKGASLIESIMHAVRDRLRPIVMTSLAFGMGVVPL
AISTGAGSGAKQAIGTGVLGGMIVGTVLGVFFVPLFFVVVQRVFKRRSTT


>gb|AJ252200.1|+|1279-4401|smeE [Stenotrophomonas maltophilia]
ATGGCACGCTTTTTCATCGATCGACCCATCTTTGCGTGGGTGATCGCCATCATCATCATGCTCGCCGGCGGCCTGGCGCTGTTCAAGCTG
CCGGTCTCGATGTACCCCAACGTCGCACCGCCGGCGGTGGAAATCAGCGCCACCTACCCGGGTGCATCGGCCAAGGTGGTCGAGGACTCG
GTGACGCAGATCATCGAGCAGAACATGAAGGGCCTTGATGGCCTGATCTACTTCTCCTCCAACAGCTCGTCCAACGGCCAGGCCACCATC
ACCCTGACCTTCGAGAGCGGCACCAACCCGGATATCGCCCAGGTGCAGGTGCAGAACAAGCTGCAGCTGGCCATGCCGCTGCTGCCGCAG
GAAGTGCAGCGGCAGGGCATCAACGTGGCCAAGTCCAGCTCGGGCTTCCTGAACGCCATCGCGTTCGTGTCCGAGAACGGCAGCATGGAC
GCCAACGACATCGCCGACTACGTCGGTTCCAATGTCGTCGACCGCCTGAGCCGCGTGCCGGGCGTGGGCAACATCCAGGTGTTCGGTGGC
AAGTACGCCATGCGCATCTGGCTGGACCCGAACAAGCTGCATACCTATGGCCTGTCGGTGCCGGAAGTGACCGCCGCGATCAAGGCGCAG
AACGCCCAGGTGGCGATCGGCCAGCTCGGCGGTGCGCCGTCGGTGAAGGGCCAGCAGCTCAACGCCACCATCAACGCGCAGTCGCGCCTG
CAGACCCCGGAACAGTTCCGAAACATCATCGTGCGCGGTGCGCAGGACGGTGCCGAGCTGCGCCTGGGTGATGTCGCCCGCGTCGAGCTG
GGTGCCGAGTCCTACGACTTCGTCACCCGCTACAACGGCCAGCCGGCCAGTGGCCTGGCGGTCACCCTGGCCACCGGCGCCAACGCGCTG
GATACCGCGGCCGGTGTGGATGCCGCGCTGGAAGACATGAAGGGCTTCTTCCCGGCCGGCCTGAAGGCCGAGATCCCGTACGACACCACC
CCGTTCGTGCGCGTGTCGATCAAGGGCGTGGTGCAGACCCTGATCGAAGCGATCGTGCTGGTGTTCGTGGTGATGTACCTGTTCCTGCAG
AACTTCCGCGCCACGCTGATCCCGACCATCGCCGTGCCGGTGGTGCTGCTGGGTACCTTCGGCGTGCTGGCGATGCTGGGCTTCTCGGTG
AACATGCTGACCATGTTCGCGATGGTGCTGGCGATCGGCCTGCTGGTGGACGATGCCATCGTGGTGGTGGAGAACGTCGAGCGCATCATG
TCCGAGGAAGGGCTGTCGCCGCTCGAAGCGACCCGCAAGTCGATGGGCCAGATCACCGGTGCGCTGGTGGGTATCGGCCTGGTGCTGTCG
GCGGTGTTCGTGCCGATGGCCTTCATGAGCGGCTCCACCGGCGTGATCTATCGCCAGTTCTCGGCCACGATTGTCTCTGCGATGGCGTTG
TCGGTGCTGGTGGCGATCGTGCTGACCCCGGCACTGTGCGCGACCATGCTCAAGCCGCTGAAGAAGGGTGAGCACCACGTCGCCCACCGT
GGCCTGGCCGGTCGCTTCTTCAATGGCTTCAACCGTGGCTTCGATCGCACCAGCGAAAGCTACCAGCGCGGCGTGCGCGGCATCATCCAC
CGTCCGTGGCGCTTCATGGGCATCGTGGCGGCCTTGTTCGTGCTGATGGGCGTGCTGTTCGTGCGCCTGCCCAGCTCGTTCCTGCCCAAC
GAAGACCAGGGTGTGCTGATGGCGCTGGTGCAGGCGCCGGTCGGTGCCACCCAGGAACGCACGCTGGAATCGATCGCGGCACTGGAAAAC
CACTTCCTGCAGAACGAGAAGGATGCGGTGGACTCGGTGTTCTCCGTGCAGGGCTTCAGCTTCGCCGGCATGGGCCAGAACGCGGGCATG
GCGTTCGTCAAGCTGAAGGACTGGAGCGAGCGTGACGCCGACAATGGCGTGATGCCGATCACCGGACGTGCGATGGCGGCCCTGGGCCAG
ATCAAGGATGCCTTCATCTTCGCCTTCCCGCCGCCGGCCATTCCGGAGCTGGGGACCGCCTCGGGCTACACCTTCTTCCTGAAGGACAAC
AGCGGCCAGGGCCACGAGGCACTGGTGGCCGCGCGCAACCAGCTGCTCGGCCTGGCCGCAGGCAGCAAGAAGCTGGCCAACGTACGCCCG
AACGGCCAGGAAGACACGCCGCAGTTCCGCATCGACATCGACGCGGCCAAGGCGACCTCGCTGGGACTGTCGATCGACCAGATCAACGGC
ACGCTGGCGGCCGCGTGGGGCAGCTCGTACATCGATGACTTCGTCGATCGTGGCCGCGTCAAGCGCGTGTTCGTGCAGGCCGACCAGGCG
TTCCGCATGGTGCCGGAGGACTTCGATCTCTGGTCCGTGAAGAACGACAAGGGTGAGATGGTGCCGTTCAGCGCCTTCGCTACCAAGCAC
TGGGACTACGGTTCGCCGCGCCTGGAACGCTACAACGGTGTGTCGGCAATGGAAATCCAGGGCGAACCGGCCCCGGGTGTCGCCTCCGGT
GATGCCATGGCCGAGATCGAACAGCTGGCCAAGCAGCTGCCGGCGGGTTTCGGCATCGAATGGACGGCGATGTCCTACCAGGAACGCCAG
GCCGGCTCGCAGACGCCGCTGCTGTACACGCTGTCGCTGATGATCGTGTTCCTGTGCCTGGCCGCGATGTATGAAAGCTGGAGCGTACCG
ACCGCGGTGCTGCTGGCGGCCCCGCTGGGTATCCTCGGCGCGGTGCTGGCCAACACCTTCAAGGGCCTGGAGCGCGACATCTACTTCCAG
GTGGCGATGCTGACCACGGTGGGCCTGACCAGCAAGAACGCGATCCTGATCGTCGAGTTCGCCAAGGAAAACCTGGAAAAGGGCGCCAGC
CTGATCGAGTCGATCATGCACGCCGTGCGCGACCGCCTGCGCCCGATCGTGATGACCTCGCTCGCCTTCGGCATGGGCGTGGTACCGCTG
GCGATCTCCACCGGTGCCGGCTCCGGCGCCAAGCAGGCGATCGGCACCGGCGTGCTCGGCGGCATGATCGTCGGCACCGTGCTCGGCGTG
TTCTTCGTGCCGCTGTTCTTCGTGGTGGTGCAGCGCGTGTTCAAGCGCAGATCCACGACGTGA