MexEF-OprN

Accession ARO:3000798
Synonym(s)NfxC mutant
DefinitionMexEF-OprN is a multidrug efflux protein expressed in the Gram-negative Pseudomonas aeruginosa. MexE is the membrane fusion protein; MexF is the inner membrane transporter; and OprN is the outer membrane channel. MexEF-OprN is associated with resistance to fluoroquinolones, chloramphenicol, and trimethoprim. Regulation of mexEF-oprN operon expression is multifaceted with the MexT activator being one of the most prominent regulatory proteins. MexEF-OprN is the only positively regulated RND pump of P. aeruginosa.
AMR Gene Familyresistance-nodulation-cell division (RND) antibiotic efflux pump
Drug Classphenicol antibiotic, diaminopyrimidine antibiotic, fluoroquinolone antibiotic
Resistance Mechanismantibiotic efflux
Efflux Componentefflux pump complex or subunit conferring antibiotic resistance
Classification8 ontology terms | Show
Parent Term(s)4 ontology terms | Show
+ confers_resistance_to_drug_class fluoroquinolone antibiotic [Drug Class]
+ resistance-nodulation-cell division (RND) antibiotic efflux pump [AMR Gene Family]
+ confers_resistance_to_antibiotic trimethoprim [Antibiotic]
+ confers_resistance_to_antibiotic chloramphenicol [Antibiotic]
Sub-Term(s)
9 ontology terms | Show
Publications

Kohler T, et al. 1999. J Bacteriol 181(20): 6300-6305. Characterization of MexT, the regulator of the MexE-MexF-OprN multidrug efflux system of Pseudomonas aeruginosa. (PMID 10515918)