MexEF-OprN

Accession ARO:3000798
Synonym(s)NfxC mutant
DefinitionMexEF-OprN is a multidrug efflux protein expressed in the Gram-negative Pseudomonas aeruginosa. MexE is the membrane fusion protein; MexF is the inner membrane transporter; and OprN is the outer membrane channel. MexEF-OprN is associated with resistance to fluoroquinolones, chloramphenicol, and trimethoprim. Regulation of mexEF-oprN operon expression is multifaceted with the MexT activator being one of the most prominent regulatory proteins. MexEF-OprN is the only positively regulated RND pump of P. aeruginosa.
AMR Gene Familyresistance-nodulation-cell division (RND) antibiotic efflux pump
Drug Classtetracycline antibiotic, monobactam, penam, acridine dye, macrolide antibiotic, diaminopyrimidine antibiotic, carbapenem, aminoglycoside antibiotic, triclosan, phenicol antibiotic, glycylcycline, fluoroquinolone antibiotic, antibacterial free fatty acids, aminocoumarin antibiotic
Resistance Mechanismantibiotic efflux
Efflux Componentefflux pump complex or subunit conferring antibiotic resistance
Classification22 ontology terms | Show
Parent Term(s)4 ontology terms | Show
+ confers_resistance_to_drug_class fluoroquinolone antibiotic [Drug Class]
+ resistance-nodulation-cell division (RND) antibiotic efflux pump [AMR Gene Family]
+ confers_resistance_to_antibiotic trimethoprim [Antibiotic]
+ confers_resistance_to_antibiotic chloramphenicol [Antibiotic]
Sub-Term(s)
9 ontology terms | Show
Publications

Kohler T, et al. 1999. J Bacteriol 181(20): 6300-6305. Characterization of MexT, the regulator of the MexE-MexF-OprN multidrug efflux system of Pseudomonas aeruginosa. (PMID 10515918)