MexEF-OprN with MvaT deletion conferring resistance to chloramphenicol and norfloxacin

Accession ARO:3004070
DefinitionA deletion of MvaT results in the overexpression of MexEF-OprN conferring resistance to chloramphenicol and norfloxacin.
AMR Gene Familyresistance-nodulation-cell division (RND) antibiotic efflux pump
Drug Classtetracycline antibiotic, glycylcycline, phenicol antibiotic, carbapenem, fluoroquinolone antibiotic, antibacterial free fatty acids, aminocoumarin antibiotic, diaminopyrimidine antibiotic, macrolide antibiotic, penam, aminoglycoside antibiotic, triclosan, monobactam, acridine dye
Resistance Mechanismantibiotic efflux
Efflux Componentefflux pump complex or subunit conferring antibiotic resistance
Classification25 ontology terms | Show
Parent Term(s)3 ontology terms | Show
+ confers_resistance_to_antibiotic chloramphenicol [Antibiotic]
+ confers_resistance_to_antibiotic norfloxacin [Antibiotic]
+ MexEF-OprN
Sub-Term(s)
4 ontology terms | Show
+ MexE part_of
+ MexF part_of
+ OprN part_of
+ MvaT part_of
Publications

Llanes C, et al. 2011. Antimicrob. Agents Chemother. 55(12):5676-84 Role of the MexEF-OprN efflux system in low-level resistance of Pseudomonas aeruginosa to ciprofloxacin. (PMID 21911574)

Westfall LW, et al. 2006. FEMS Microbiol. Lett. 255(2):247-54 mvaT mutation modifies the expression of the Pseudomonas aeruginosa multidrug efflux operon mexEF-oprN. (PMID 16448502)

Resistomes

Prevalence of MexEF-OprN with MvaT deletion conferring resistance to chloramphenicol and norfloxacin among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI for 82 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).

Prevalence: efflux pump system meta-model

SpeciesNCBI ChromosomeNCBI PlasmidNCBI WGS
No prevalence data


Detection Models

Model Name: MexEF-OprN with MvaT deletion conferring resistance to chloramphenicol and norfloxacin

Model Description: A deletion of MvaT results in the overexpression of MexEF-OprN conferring resistance to chloramphenicol and norfloxacin.

OprNMexEMexFMvaT