MexF

Accession ARO:3000804
CARD Short NameMexF
DefinitionMexF is the multidrug inner membrane transporter of the MexEF-OprN complex. mexF corresponds to 2 loci in Pseudomonas aeruginosa PAO1 (gene name: mexF/mexB) and 4 loci in Pseudomonas aeruginosa LESB58 (gene name: mexD/mexB).
AMR Gene Familyresistance-nodulation-cell division (RND) antibiotic efflux pump
Drug Classdiaminopyrimidine antibiotic, phenicol antibiotic, fluoroquinolone antibiotic
Resistance Mechanismantibiotic efflux
Efflux Componentefflux pump complex or subunit conferring antibiotic resistance
Resistomes with Perfect MatchesPseudomonas aeruginosag+p+wgs
Resistomes with Sequence VariantsPseudomonas aeruginosag+p+wgs
Classification15 ontology terms | Show
Parent Term(s)5 ontology terms | Show
Publications

Kohler T, et al. 1999. J Bacteriol 181(20): 6300-6305. Characterization of MexT, the regulator of the MexE-MexF-OprN multidrug efflux system of Pseudomonas aeruginosa. (PMID 10515918)

Resistomes

Prevalence of MexF among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 413 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).

Prevalence: protein homolog model (view sequences)

SpeciesNCBI ChromosomeNCBI PlasmidNCBI WGSNCBI GI
Pseudomonas aeruginosa73.31%0.29%49.12%0%
Show Perfect Only


Detection Models

Model Type: protein homolog model

Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.

Bit-score Cut-off (blastP): 2110


>gb|AAG05882.1|+|MexF [Pseudomonas aeruginosa PAO1]
MNFSQFFIQRPIFAAVLSLLILIGGAISLFQLPISEYPEVVPPTVVVRANFPGANPKVIGETVASPLEQAITGVENMLYMSSQSTSDGKL
TLTITFALGTDLDNAQVQVQNRVTRTEPKLPEEVTRLGITVDKASPDLTMVVHLTSPDNRYDMLYLSNYAVLNVKDELARLDGVGDVQLF
GLGDYSLRVWLDPNKVASRNLTATDVVNAIREQNRQVAAGTLGAPPAPSDTSFQLSINTQGRLVTEEEFENIIIRAGANGEITRLRDIAR
VELGSNQYALRSLLNNKPAVAIPIFQRPGSNAIEISNLVREKMAELKHSFPQGMDYSIVYDPTIFVRGSIEAVVHTLFEALVLVVLVVIL
FLQTWRASIIPLAAVPVSLIGTFAVMHMLGFSLNALSLFGLVLAIGIVVDDAIVVVENVERNIGLGLKPVEATKRAMREVTGPIIATALV
LCAVFIPTAFISGLTGQFYRQFALTIAISTVISAFNSLTLSPALAAVLLKGHHEPKDRFSVFLDKLLGSWLFRPFNRFFDRASHGYVGTV
NRVLRGSSIALLVYGGLMVLTYFGFSSTPTGFVPQQDKQYLVAFAQLPDAASLDRTEAVIKQMSEIALAQPGVADSVAFPGLSINGFTNS
PNSGIVFTPLKPFDERKDPSQSAGAIAAALNAKYADIQDAYIAIFPPPPVQGLGTIGGFRLQIEDRGNQGYEELFKQTQNIITKARALPE
LEPSSVFSSYQVNVPQIDADIDREKAKTHGVAISDIFDTLQVYLGSLYANDFNRFGRTYQVNVQAEQQFRLEPEQIGQLKVRNNLGEMVP
LASFIKVSDTSGPDRVMHYNGFITAELNGAPAAGYSSGQAQAAIEKLLKEELPNGMTYEWTELTYQQILAGNTALFVFPLCVLLAFLVLA
AQYESWSLPLAVILIVPMTLLSAITGVILAGSDNNIFTQIGLIVLVGLACKNAILIVEFAKDKQEEGMDRVAAVLEACRLRLRPILMTSI
AFIMGVVPLVISTGAGAEMRHAMGVAVFSGMIGVTFFGLLLTPVFYVLIRRFVENREARRAANDKGLPEVHA


>gb|AE004091.2|+|2810009-2813197|MexF [Pseudomonas aeruginosa PAO1]
ATGAATTTCTCCCAATTCTTCATCCAGCGGCCGATCTTCGCCGCGGTGCTGTCGCTGCTGATCCTGATTGGCGGCGCCATCTCCCTGTTC
CAGCTACCCATCAGCGAATACCCGGAAGTGGTGCCGCCGACCGTCGTGGTCCGCGCCAACTTCCCCGGCGCCAACCCGAAAGTCATCGGC
GAGACCGTCGCCTCTCCCCTTGAACAGGCGATCACCGGGGTGGAGAACATGCTCTACATGTCCTCCCAGTCGACCTCCGACGGCAAGCTG
ACCCTGACCATCACCTTCGCCCTCGGCACCGACCTGGACAACGCCCAGGTGCAGGTGCAGAACCGCGTCACCCGGACCGAGCCGAAGCTC
CCGGAAGAAGTGACCCGGCTCGGCATCACCGTCGACAAGGCCTCGCCCGACCTGACCATGGTCGTGCACCTGACCTCGCCGGATAACCGC
TACGACATGCTCTACCTGTCGAACTACGCGGTGCTCAACGTGAAGGACGAACTGGCCCGCCTCGACGGCGTCGGCGACGTCCAGTTGTTC
GGCCTCGGCGACTATTCGCTGCGCGTCTGGCTGGACCCGAACAAGGTCGCCTCGCGCAACCTCACCGCCACCGACGTGGTCAACGCCATC
CGCGAGCAGAACCGCCAGGTCGCCGCCGGCACCCTGGGCGCGCCGCCGGCGCCGAGCGATACCAGCTTCCAGTTGTCGATCAACACCCAG
GGTCGCCTGGTCACCGAGGAAGAGTTCGAGAACATCATCATCCGCGCCGGCGCCAACGGCGAGATCACCCGTCTGCGCGACATCGCCCGG
GTCGAGCTGGGCTCCAACCAGTACGCCCTGCGTTCGCTGCTGAACAACAAGCCGGCGGTGGCGATCCCGATCTTCCAGCGTCCCGGCTCG
AACGCCATCGAGATCTCCAACCTGGTGCGGGAGAAGATGGCCGAGCTGAAGCACAGCTTCCCGCAAGGCATGGACTACTCCATCGTCTAC
GACCCGACCATCTTCGTCCGCGGCTCCATCGAGGCGGTGGTGCACACCCTGTTCGAAGCCCTGGTGCTGGTGGTGCTGGTGGTGATCCTG
TTCCTGCAGACCTGGCGCGCCTCGATCATCCCGCTGGCCGCGGTGCCGGTGTCGCTGATCGGCACCTTCGCGGTGATGCACATGCTCGGC
TTCTCGCTCAACGCGCTGTCGCTGTTCGGCCTGGTGCTGGCCATCGGCATCGTGGTGGACGACGCCATCGTGGTGGTGGAGAACGTCGAG
CGCAACATCGGCCTCGGCCTCAAGCCGGTGGAAGCCACCAAGCGTGCCATGCGCGAGGTGACCGGGCCGATCATCGCCACGGCGCTGGTG
CTCTGCGCGGTGTTCATCCCGACCGCGTTCATCTCCGGCCTCACCGGGCAGTTCTACCGCCAGTTCGCCCTGACCATCGCGATCTCCACG
GTGATCTCGGCGTTCAACTCGCTGACCCTGTCGCCAGCGCTGGCGGCGGTCCTGCTCAAGGGCCACCACGAGCCGAAGGACCGCTTCTCG
GTGTTCCTCGACAAGCTCCTCGGCAGTTGGCTGTTCCGTCCGTTCAACCGTTTCTTCGACCGCGCCAGCCATGGCTACGTCGGCACGGTG
AACCGGGTCCTGCGCGGCAGCTCGATCGCCCTGCTGGTCTACGGCGGACTGATGGTGCTGACCTACTTCGGCTTCTCCAGCACGCCGACC
GGTTTCGTCCCGCAGCAGGACAAGCAGTACCTGGTGGCCTTCGCCCAGTTGCCCGACGCGGCCAGCCTGGACCGTACCGAGGCGGTGATC
AAGCAGATGTCCGAGATCGCCCTGGCGCAGCCCGGCGTGGCGGACTCGGTGGCCTTCCCCGGCCTGTCGATCAACGGCTTCACCAACAGC
CCGAACAGCGGCATCGTGTTCACCCCGCTGAAGCCGTTCGACGAGCGCAAGGACCCGAGCCAGTCGGCCGGGGCCATCGCCGCCGCGCTG
AACGCCAAGTACGCCGACATTCAGGACGCCTACATCGCGATCTTCCCGCCGCCGCCGGTACAGGGGCTGGGGACCATCGGCGGCTTCCGC
CTGCAGATCGAGGACCGTGGCAACCAGGGCTACGAGGAGCTGTTCAAGCAGACCCAGAACATCATCACCAAGGCCCGTGCGCTGCCTGAG
CTGGAACCCAGCTCGGTGTTCTCCAGCTACCAGGTCAACGTGCCGCAGATCGACGCCGACATCGACCGCGAGAAGGCCAAGACCCACGGC
GTGGCGATCAGCGACATCTTCGACACCCTGCAGGTCTACCTCGGCTCGCTGTACGCGAACGACTTCAACCGCTTCGGCCGTACCTATCAG
GTCAACGTCCAGGCCGAGCAGCAGTTCCGCCTCGAACCCGAGCAGATCGGCCAGCTGAAGGTGCGCAACAACCTCGGCGAGATGGTCCCG
CTGGCGTCCTTCATCAAGGTCAGCGACACCTCCGGTCCGGACCGTGTGATGCACTACAACGGCTTCATCACCGCCGAACTCAACGGCGCC
CCGGCCGCGGGCTACAGCTCCGGCCAGGCGCAGGCGGCGATCGAGAAGCTGCTGAAGGAGGAACTGCCCAACGGCATGACCTACGAGTGG
ACCGAGCTGACCTACCAGCAGATCCTCGCCGGCAATACCGCGCTGTTCGTCTTCCCGCTCTGCGTGCTGCTGGCCTTCCTCGTGCTGGCC
GCCCAGTACGAGAGCTGGAGCCTACCGCTGGCGGTGATCCTGATCGTGCCGATGACCCTGCTGTCGGCGATCACCGGGGTGATCCTGGCC
GGCAGCGACAACAACATCTTTACCCAGATCGGCCTGATCGTTCTGGTGGGGCTGGCGTGCAAGAACGCGATCCTGATCGTCGAGTTCGCC
AAGGACAAGCAGGAGGAAGGCATGGACCGCGTCGCCGCGGTGCTGGAAGCCTGCCGCCTGCGCCTGCGGCCGATCCTGATGACGTCCATC
GCCTTCATCATGGGTGTGGTGCCGCTGGTGATCTCCACCGGCGCCGGCGCCGAGATGCGCCATGCGATGGGCGTGGCGGTGTTCTCCGGG
ATGATCGGGGTGACCTTCTTCGGCCTGCTGCTGACGCCGGTGTTCTACGTCCTCATCCGCCGCTTCGTGGAGAACCGCGAAGCGCGCCGC
GCCGCCAACGACAAAGGCCTGCCAGAGGTGCATGCATGA