| Accession | ARO:3004068 |
| CARD Short Name | Paer_MexS_MULT |
| Definition | The MexEF–OprN efflux pump with MexS mutations conferring resistance to chloramphenicol and ciprofloxacin. The model includes the MexT regulator, as MexS is suggested to inactivate MexT. |
| AMR Gene Family | resistance-nodulation-cell division (RND) antibiotic efflux pump |
| Drug Class | diaminopyrimidine antibiotic, phenicol antibiotic, fluoroquinolone antibiotic |
| Resistance Mechanism | antibiotic efflux |
| Efflux Component | efflux pump complex or subunit conferring antibiotic resistance |
| Classification | 12 ontology terms | Show + process or component of antibiotic biology or chemistry + mechanism of antibiotic resistance + antibiotic efflux [Resistance Mechanism] + determinant of antibiotic resistance + antibiotic molecule + efflux pump complex or subunit conferring antibiotic resistance [Efflux Component] + diaminopyrimidine antibiotic [Drug Class] + phenicol antibiotic [Drug Class] + trimethoprim [Antibiotic] + chloramphenicol [Antibiotic] + resistance-nodulation-cell division (RND) antibiotic efflux pump [AMR Gene Family] + fluoroquinolone antibiotic [Drug Class] |
| Parent Term(s) | 4 ontology terms | Show + MexEF-OprN + confers_resistance_to_antibiotic ciprofloxacin [Antibiotic] + confers_resistance_to_antibiotic chloramphenicol [Antibiotic] + confers_resistance_to_antibiotic trimethoprim [Antibiotic] |
| Sub-Term(s) | 5 ontology terms | Show |
| Publications | Richardot C, et al. 2016. Antimicrob. Agents Chemother. 60(4):2302-10 Amino Acid Substitutions Account for Most MexS Alterations in Clinical nfxC Mutants of Pseudomonas aeruginosa. (PMID 26833155) |
Prevalence of MexEF-OprN with MexS mutations conferring resistance to chloramphenicol, ciprofloxacin, and trimethoprim among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 413 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).
| Species | NCBI Chromosome | NCBI Plasmid | NCBI WGS | NCBI GI |
|---|---|---|---|---|
| No prevalence data | ||||
Model Name: MexEF-OprN with MexS mutations conferring resistance to chloramphenicol, ciprofloxacin, and trimethoprim
Model Description: The MexEF–OprN efflux pump with MexS mutations conferring resistance to chloramphenicol and ciprofloxacin. The model includes the MexT regulator, as MexS is suggested to inactivate MexT.
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