trimethoprim [Antibiotic]

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Accession ARO:3000188
DefinitionTrimethoprim is a synthetic 5-(3,4,5- trimethoxybenzyl) pyrimidine inhibitor of dihydrofolate reductase, inhibiting synthesis of tetrahydrofolic acid. Tetrahydrofolic acid is an essential precursor in the de novo synthesis of the DNA nucleotide thymidine. Trimethoprim is a bacteriostatic antibiotic mainly used in the prophylaxis and treatment of urinary tract infections in combination with sulfamethoxazole, a sulfonamide antibiotic.
Drug Classdiaminopyrimidine antibiotic
Classification2 ontology terms | Show
Parent Term(s)1 ontology terms | Show
Sub-Term(s)
24 ontology terms | Show
+ antibiotic sensitive dihydrofolate reductase targeted_by_antibiotic
+ dfrA18 confers_resistance_to_antibiotic
+ Staphylococcys aureus LmrS confers_resistance_to_antibiotic
+ trimethoprim resistant dihydrofolate reductase dfr [AMR Gene Family] confers_resistance_to_antibiotic
+ MexPQ-OpmE confers_resistance_to_antibiotic
+ MexAB-OprM confers_resistance_to_antibiotic
+ MexCD-OprJ confers_resistance_to_antibiotic
+ MexEF-OprN confers_resistance_to_antibiotic
+ AdeIJK confers_resistance_to_antibiotic
+ oqxAB confers_resistance_to_antibiotic
+ MexEF-OprN with MexT mutation conferring resistance to chloramphenicol, ciprofloxacin, and trimethoprim confers_resistance_to_antibiotic
+ MexEF-OprN with MexS mutations conferring resistance to chloramphenicol, ciprofloxacin, and trimethoprim confers_resistance_to_antibiotic
+ MexAB-OprM with MexR mutations confers resistance to multiple antibiotics confers_resistance_to_antibiotic
+ dfrA5 confers_resistance_to_antibiotic
+ dfrA1 confers_resistance_to_antibiotic
+ dfrA8 confers_resistance_to_antibiotic
+ dfrA14 confers_resistance_to_antibiotic
+ dfrA15 confers_resistance_to_antibiotic
+ dfrA17 confers_resistance_to_antibiotic
+ dfrA15b confers_resistance_to_drug_class
+ dfrA3b confers_resistance_to_drug_class
+ dfrA6 from Proteus mirabilis confers_resistance_to_drug_class
+ dfrI confers_resistance_to_drug_class
+ trimethoprim-sulfamethoxazole [Antibiotic] has_part
Publications

Skold O. 2001. Vet Res 32(3-4): 261-273. Resistance to trimethoprim and sulfonamides. (PMID 11432417)

Brochet M, et al. 2008. J Bacteriol 190(2): 672-680. A naturally occurring gene amplification leading to sulfonamide and trimethoprim resistance in Streptococcus agalactiae. (PMID 18024520)