| Accession | ARO:3000188 |
| Definition | Trimethoprim is a synthetic 5-(3,4,5- trimethoxybenzyl) pyrimidine inhibitor of dihydrofolate reductase, inhibiting synthesis of tetrahydrofolic acid. Tetrahydrofolic acid is an essential precursor in the de novo synthesis of the DNA nucleotide thymidine. Trimethoprim is a bacteriostatic antibiotic mainly used in the prophylaxis and treatment of urinary tract infections in combination with sulfamethoxazole, a sulfonamide antibiotic. |
| Drug Class | diaminopyrimidine antibiotic |
| Classification | 2 ontology terms | Show |
| Parent Term(s) | 1 ontology terms | Show + diaminopyrimidine antibiotic [Drug Class] |
| Sub-Term(s) | 24 ontology terms | Show + antibiotic sensitive dihydrofolate reductase targeted_by_antibiotic + dfrA18 confers_resistance_to_antibiotic + Staphylococcys aureus LmrS confers_resistance_to_antibiotic + trimethoprim resistant dihydrofolate reductase dfr [AMR Gene Family] confers_resistance_to_antibiotic + MexPQ-OpmE confers_resistance_to_antibiotic + MexAB-OprM confers_resistance_to_antibiotic + MexCD-OprJ confers_resistance_to_antibiotic + MexEF-OprN confers_resistance_to_antibiotic + AdeIJK confers_resistance_to_antibiotic + oqxAB confers_resistance_to_antibiotic + MexEF-OprN with MexT mutation conferring resistance to chloramphenicol, ciprofloxacin, and trimethoprim confers_resistance_to_antibiotic + MexEF-OprN with MexS mutations conferring resistance to chloramphenicol, ciprofloxacin, and trimethoprim confers_resistance_to_antibiotic + MexAB-OprM with MexR mutations confers resistance to multiple antibiotics confers_resistance_to_antibiotic + dfrA5 confers_resistance_to_antibiotic + dfrA1 confers_resistance_to_antibiotic + dfrA8 confers_resistance_to_antibiotic + dfrA14 confers_resistance_to_antibiotic + dfrA15 confers_resistance_to_antibiotic + dfrA17 confers_resistance_to_antibiotic + dfrA15b confers_resistance_to_drug_class + dfrA3b confers_resistance_to_drug_class + dfrA6 from Proteus mirabilis confers_resistance_to_drug_class + dfrI confers_resistance_to_drug_class + trimethoprim-sulfamethoxazole [Antibiotic] has_part |
| Publications | Skold O. 2001. Vet Res 32(3-4): 261-273. Resistance to trimethoprim and sulfonamides. (PMID 11432417) Brochet M, et al. 2008. J Bacteriol 190(2): 672-680. A naturally occurring gene amplification leading to sulfonamide and trimethoprim resistance in Streptococcus agalactiae. (PMID 18024520) |
