| Accession | ARO:3002865 |
| CARD Short Name | dfrC |
| Definition | dfrC is a chromosome-encoded dihydrofolate reductase found in Staphylococcus aureus. |
| AMR Gene Family | trimethoprim resistant dihydrofolate reductase dfr |
| Drug Class | diaminopyrimidine antibiotic |
| Resistance Mechanism | antibiotic target replacement |
| Resistomes with Perfect Matches | Staphylococcus epidermidisg+wgs+gi |
| Resistomes with Sequence Variants | Enterococcus faecalisp+wgs, Pseudomonas aeruginosawgs, Serratia marcescenswgs, Staphylococcus aureusg+p+wgs+gi, Staphylococcus capitisg+wgs, Staphylococcus epidermidisg+p+wgs+gi, Staphylococcus equorumwgs, Staphylococcus haemolyticuswgs, Staphylococcus hominiswgs, Staphylococcus pseudintermediuswgs, Staphylococcus saprophyticusp+wgs, Staphylococcus warneriwgs, Streptococcus pneumoniaewgs |
| Classification | 9 ontology terms | Show + process or component of antibiotic biology or chemistry + mechanism of antibiotic resistance + determinant of antibiotic resistance + antibiotic molecule + antibiotic target replacement [Resistance Mechanism] + antibiotic target replacement protein + diaminopyrimidine antibiotic [Drug Class] + trimethoprim [Antibiotic] + antibiotic resistant dihydrofolate reductase |
| Parent Term(s) | 3 ontology terms | Show + trimethoprim resistant dihydrofolate reductase dfr [AMR Gene Family] + derives_from antibiotic sensitive dihydrofolate reductase + confers_resistance_to_antibiotic trimethoprim [Antibiotic] |
| Publications | Dale GE, et al. 1995. J Bacteriol 177(11): 2965-2970. Characterization of the gene for the chromosomal dihydrofolate reductase (DHFR) of Staphylococcus epidermidis ATCC 14990: the origin of the trimethoprim-resistant S1 DHFR from Staphylococcus aureus?. (PMID 7768789) |
Prevalence of dfrC among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 413 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).
| Species | NCBI Chromosome | NCBI Plasmid | NCBI WGS | NCBI GI |
|---|---|---|---|---|
| Enterococcus faecalis | 0% | 0.49% | 1.19% | 0% |
| Pseudomonas aeruginosa | 0% | 0% | 0.01% | 0% |
| Serratia marcescens | 0% | 0% | 0.13% | 0% |
| Staphylococcus aureus | 1.4% | 0.67% | 3.32% | 1.43% |
| Staphylococcus capitis | 20% | 0% | 6.33% | 0% |
| Staphylococcus epidermidis | 100% | 0.86% | 67.45% | 5.71% |
| Staphylococcus equorum | 0% | 0% | 3.57% | 0% |
| Staphylococcus haemolyticus | 0% | 0% | 8.57% | 0% |
| Staphylococcus hominis | 0% | 0% | 1.46% | 0% |
| Staphylococcus pseudintermedius | 0% | 0% | 0.26% | 0% |
| Staphylococcus saprophyticus | 0% | 2.7% | 1.4% | 0% |
| Staphylococcus warneri | 0% | 0% | 5.74% | 0% |
| Streptococcus pneumoniae | 0% | 0% | 0.01% | 0% |
Model Type: protein homolog model
Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.
Bit-score Cut-off (blastP): 300