Accession ARO:3002865
CARD Short NamedfrC
DefinitiondfrC is a chromosome-encoded dihydrofolate reductase found in Staphylococcus aureus.
AMR Gene Familytrimethoprim resistant dihydrofolate reductase dfr
Drug Classdiaminopyrimidine antibiotic
Resistance Mechanismantibiotic target replacement
Resistomes with Perfect MatchesStaphylococcus epidermidisg+wgs+gi
Resistomes with Sequence VariantsEnterococcus faecalisp+wgs, Pseudomonas aeruginosawgs, Serratia marcescenswgs, Staphylococcus aureusg+p+wgs+gi, Staphylococcus capitisg+wgs, Staphylococcus epidermidisg+p+wgs+gi, Staphylococcus equorumwgs, Staphylococcus haemolyticuswgs, Staphylococcus hominiswgs, Staphylococcus pseudintermediuswgs, Staphylococcus saprophyticusp+wgs, Staphylococcus warneriwgs, Streptococcus pneumoniaewgs
Classification9 ontology terms | Show
Parent Term(s)3 ontology terms | Show
+ trimethoprim resistant dihydrofolate reductase dfr [AMR Gene Family]
+ derives_from antibiotic sensitive dihydrofolate reductase
+ confers_resistance_to_antibiotic trimethoprim [Antibiotic]

Dale GE, et al. 1995. J Bacteriol 177(11): 2965-2970. Characterization of the gene for the chromosomal dihydrofolate reductase (DHFR) of Staphylococcus epidermidis ATCC 14990: the origin of the trimethoprim-resistant S1 DHFR from Staphylococcus aureus?. (PMID 7768789)


Prevalence of dfrC among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 413 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).

Prevalence: protein homolog model (view sequences)

SpeciesNCBI ChromosomeNCBI PlasmidNCBI WGSNCBI GI
Enterococcus faecalis0%0.49%1.19%0%
Pseudomonas aeruginosa0%0%0.01%0%
Serratia marcescens0%0%0.13%0%
Staphylococcus aureus1.4%0.67%3.32%1.43%
Staphylococcus capitis20%0%6.33%0%
Staphylococcus epidermidis100%0.86%67.45%5.71%
Staphylococcus equorum0%0%3.57%0%
Staphylococcus haemolyticus0%0%8.57%0%
Staphylococcus hominis0%0%1.46%0%
Staphylococcus pseudintermedius0%0%0.26%0%
Staphylococcus saprophyticus0%2.7%1.4%0%
Staphylococcus warneri0%0%5.74%0%
Streptococcus pneumoniae0%0%0.01%0%
Show Perfect Only

Detection Models

Model Type: protein homolog model

Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.

Bit-score Cut-off (blastP): 300

>gb|AAO04716.1|-|dfrC [Staphylococcus epidermidis ATCC 12228]

>gb|AE015929.1|-|1128934-1129419|dfrC [Staphylococcus epidermidis ATCC 12228]