trimethoprim resistant dihydrofolate reductase dfr [AMR Gene Family]

Accession ARO:3001218
DefinitionAlternative dihydropteroate synthase dfr present on plasmids produces alternate proteins that are less sensitive to trimethoprim from inhibiting its role in folate synthesis, thus conferring trimethoprim resistance.
Drug Classdiaminopyrimidine antibiotic
Resistance Mechanismantibiotic target replacement
Classification7 ontology terms | Show
Parent Term(s)4 ontology terms | Show
+ derives_from antibiotic sensitive dihydrofolate reductase
+ antibiotic resistant dihydrofolate reductase
+ confers_resistance_to_drug_class diaminopyrimidine antibiotic [Drug Class]
+ confers_resistance_to_antibiotic trimethoprim [Antibiotic]
59 ontology terms | Show

Brolund A, et al. 2010. PLoS One 5(2): E9233. Molecular characterisation of trimethoprim resistance in Escherichia coli and Klebsiella pneumoniae during a two year intervention on trimethoprim use. (PMID 20169085)