antibiotic sensitive dihydrofolate reductase

Accession ARO:3000745
Synonym(s)FolA
DefinitionDihydrofolate reductase synthesizes the co-enzyme tetrahydrofolic acid, which is also an essential precursor in the de novo synthesis of the DNA nucleotide thymidine.
Drug Classdiaminopyrimidine antibiotic
Classification2 ontology terms | Show
Parent Term(s)6 ontology terms | Show
+ targeted_by diaminopyrimidine antibiotic [Drug Class]
+ targeted_by_antibiotic trimethoprim [Antibiotic]
+ targeted_by_antibiotic brodimoprim [Antibiotic]
+ targeted_by_antibiotic tetroxoprim [Antibiotic]
+ targeted_by_antibiotic iclaprim [Antibiotic]
+ folate synthesis enzyme targeted by antibiotic
Sub-Term(s)
31 ontology terms | Show
+ trimethoprim resistant dihydrofolate reductase dfr [AMR Gene Family] derives_from
+ dfrF derives_from
+ dfrB6 derives_from
+ dfrA26 derives_from
+ dfrA23 derives_from
+ dfrE derives_from
+ dfrA16 derives_from
+ dfrB1 derives_from
+ dfrA22 derives_from
+ dfrA20 derives_from
+ dfrB3 derives_from
+ dfrD derives_from
+ dfrA8 derives_from
+ dfrA10 derives_from
+ dfrA21 derives_from
+ dfrB2 derives_from
+ dfrK derives_from
+ dfrA5 derives_from
+ dfrA13 derives_from
+ dfrA19 derives_from
+ dfrA3 derives_from
+ dfrA12 derives_from
+ dfrA1 derives_from
+ dfrG derives_from
+ dfrA15 derives_from
+ dfrA17 derives_from
+ dfrA7 derives_from
+ dfrC derives_from
+ dfrA14 derives_from
+ dfrA24 derives_from
+ dfrA25 derives_from
Publications

Myllykallio H, et al. 2003. Trends Microbiol 11(5): 220-223. Life without dihydrofolate reductase FolA. (PMID 12781525)