Accession | ARO:3003013 |
CARD Short Name | dfrA15 |
Definition | dfrA15 is an integron-encoded dihydrofolate reductase found in Vibrio cholerae. |
AMR Gene Family | trimethoprim resistant dihydrofolate reductase dfr |
Drug Class | diaminopyrimidine antibiotic |
Resistance Mechanism | antibiotic target replacement |
Resistomes with Perfect Matches | Aeromonas caviaewgs, Aeromonas veroniiwgs, Citrobacter amalonaticuswgs, Citrobacter werkmaniiwgs, Enterobacter cloacaewgs, Enterobacter hormaecheip+wgs, Escherichia albertiip, Escherichia colip+wgs, Klebsiella michiganensiswgs, Klebsiella pneumoniaep+wgs, Klebsiella quasipneumoniaewgs, Morganella morganiiwgs, Providencia rettgerip+wgs, Pseudomonas aeruginosawgs, Salmonella entericap+wgs, Shigella sonneiwgs, Vibrio choleraep+wgs |
Resistomes with Sequence Variants | Aeromonas caviaewgs, Aeromonas veroniiwgs, Citrobacter amalonaticuswgs, Citrobacter werkmaniiwgs, Corynebacterium diphtheriaewgs, Enterobacter cloacaewgs, Enterobacter hormaecheip+wgs, Escherichia albertiip, Escherichia colip+wgs, Klebsiella michiganensiswgs, Klebsiella pneumoniaep+wgs, Klebsiella quasipneumoniaewgs, Morganella morganiiwgs, Providencia rettgerip+wgs, Pseudomonas aeruginosawgs, Salmonella entericap+wgs, Shewanella putrefaciensg+p, Shigella sonneiwgs, Vibrio choleraep+wgs |
Classification | 9 ontology terms | Show + process or component of antibiotic biology or chemistry + mechanism of antibiotic resistance + antibiotic molecule + antibiotic target replacement [Resistance Mechanism] + determinant of antibiotic resistance + antibiotic target replacement protein + diaminopyrimidine antibiotic [Drug Class] + trimethoprim [Antibiotic] + antibiotic resistant dihydrofolate reductase |
Parent Term(s) | 3 ontology terms | Show + confers_resistance_to_antibiotic trimethoprim [Antibiotic] + derives_from antibiotic sensitive dihydrofolate reductase + trimethoprim resistant dihydrofolate reductase dfr [AMR Gene Family] |
Publications | Ceccarelli D, et al. 2006. J Antimicrob Chemother 58(5): 1095-1097. Prevalence of aadA1 and dfrA15 class 1 integron cassettes and SXT circulation in Vibrio cholerae O1 isolates from Africa. (PMID 16980697) |
Prevalence of dfrA15 among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 263 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).
Species | NCBI Chromosome | NCBI Plasmid | NCBI WGS | NCBI GI |
---|---|---|---|---|
Aeromonas caviae | 0% | 0% | 0.9% | 0% |
Aeromonas veronii | 0% | 0% | 3.97% | 0% |
Citrobacter amalonaticus | 0% | 0% | 2.08% | 0% |
Citrobacter werkmanii | 0% | 0% | 9.52% | 0% |
Corynebacterium diphtheriae | 0% | 0% | 0.39% | 0% |
Enterobacter cloacae | 0% | 0% | 1.36% | 0% |
Enterobacter hormaechei | 0% | 0.17% | 3.66% | 0% |
Escherichia albertii | 0% | 2.63% | 0% | 0% |
Escherichia coli | 0% | 0.04% | 0.27% | 0% |
Klebsiella michiganensis | 0% | 0% | 0.65% | 0% |
Klebsiella pneumoniae | 0% | 0.03% | 0.66% | 0% |
Klebsiella quasipneumoniae | 0% | 0% | 0.9% | 0% |
Morganella morganii | 0% | 0% | 2.08% | 0% |
Providencia rettgeri | 0% | 3.03% | 0.86% | 0% |
Pseudomonas aeruginosa | 0% | 0% | 0.04% | 0% |
Salmonella enterica | 0% | 0.21% | 0.23% | 0% |
Shewanella putrefaciens | 11.11% | 25% | 0% | 0% |
Shigella sonnei | 0% | 0% | 0.15% | 0% |
Vibrio cholerae | 0% | 6.25% | 0.14% | 0% |
Model Type: protein homolog model
Model Definition: The protein homolog model is an AMR detection model. Protein homolog models detect a protein sequence based on its similarity to a curated reference sequence. A protein homolog model has only one parameter: a curated BLASTP bitscore cutoff for determining the strength of a match. Protein homolog model matches to reference sequences are categorized on three criteria: perfect, strict and loose. A perfect match is 100% identical to the reference sequence along its entire length; a strict match is not identical but the bitscore of the matched sequence is greater than the curated BLASTP bitscore cutoff. Loose matches are other sequences with a match bitscore less than the curated BLASTP bitscore.
Bit-score Cut-off (blastP): 300