diaminopyrimidine antibiotic [Drug Class]

Accession ARO:3000171
DefinitionDiaminopyrimidines are a class of organic compounds containing a pyrimidine ring substituted by two amine groups. They are inhibitors of dihydrofolate reductase, an enzyme critical for DNA synthesis.
Classification1 ontology terms | Show
Parent Term(s)1 ontology terms | Show
6 ontology terms | Show
+ trimethoprim [Antibiotic]
+ brodimoprim [Antibiotic]
+ tetroxoprim [Antibiotic]
+ iclaprim [Antibiotic]
+ antibiotic sensitive dihydrofolate reductase targeted_by
+ trimethoprim resistant dihydrofolate reductase dfr [AMR Gene Family] confers_resistance_to_drug_class

Baccanari DP and Kuyper LF. 1993. J Chemother 5(6): 393-399. Basis of selectivity of antibacterial diaminopyrimidines. (PMID 8195830)