iclaprim [Antibiotic]

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Accession ARO:3000337
Synonym(s)AR-100 RO-48-2622
DefinitionIclaprim is a bactericidal compound that inhibits dihydrofolate reductase. It is used against clinically important Gram-positive pathogens, including methicillin-sensitive Staphylococcus aureus and methicillin-resistant S. aureus.
Drug Classdiaminopyrimidine antibiotic
Classification2 ontology terms | Show
Parent Term(s)1 ontology terms | Show
2 ontology terms | Show
+ antibiotic sensitive dihydrofolate reductase targeted_by_antibiotic
+ dfrL confers_resistance_to_antibiotic

Oefner C, et al. 2009. Acta Crystallogr D Biol Crystallogr 65(PT 8): 751-757. Inhibitory properties and X-ray crystallographic study of the binding of AR-101, AR-102 and iclaprim in ternary complexes with NADPH and dihydrofolate reductase from Staphylococcus aureus. (PMID 19622858)

Sader HS, et al. 2009. Antimicrob Agents Chemother 53(5): 2171-2175. Potency and bactericidal activity of iclaprim against recent clinical gram-positive isolates. (PMID 19289528)