| Accession | ARO:3002860 |
| CARD Short Name | dfrA17 |
| Definition | dfrA17 is an integron-encoded dihydrofolate reductase found in Escherichia coli. |
| AMR Gene Family | trimethoprim resistant dihydrofolate reductase dfr |
| Drug Class | diaminopyrimidine antibiotic |
| Resistance Mechanism | antibiotic target replacement |
| Resistomes with Perfect Matches | Citrobacter freundiiwgs, Escherichia colig+p+wgs, Klebsiella aerogenesp, Klebsiella michiganensiswgs, Klebsiella pneumoniaewgs, Klebsiella quasipneumoniaewgs, Morganella morganiiwgs, Proteus mirabiliswgs, Salmonella entericawgs, Shigella boydiiwgs, Shigella flexnerig+wgs, Shigella sonneiwgs |
| Resistomes with Sequence Variants | Acinetobacter baumanniig+wgs, Aeromonas hydrophilap+wgs, Aeromonas veroniig+wgs, Alcaligenes faecaliswgs, Burkholderia cenocepaciawgs, Citrobacter amalonaticusp, Citrobacter freundiiwgs, Citrobacter portucalensiswgs, Citrobacter werkmaniiwgs, Enterobacter asburiaep, Enterobacter cloacaewgs, Enterobacter hormaecheip+wgs, Enterobacter kobeig, Escherichia colig+p+wgs+gi, Escherichia fergusoniip+wgs, Klebsiella aerogenesp+wgs, Klebsiella michiganensisg+wgs, Klebsiella oxytocawgs, Klebsiella pneumoniaeg+p+wgs+gi, Klebsiella quasipneumoniaewgs, Laribacter hongkongensisgi, Morganella morganiig+wgs+gi, Pasteurella multocidawgs, Proteus mirabilisg+p+wgs+gi, Providencia alcalifaciensg, Providencia rettgerip+wgs, Salmonella entericag+p+wgs+gi, Shigella boydiiwgs, Shigella dysenteriaewgs, Shigella flexnerig+p+wgs, Shigella sonneip+wgs+gi, Vibrio parahaemolyticuswgs, Yersinia enterocoliticawgs |
| Classification | 9 ontology terms | Show + process or component of antibiotic biology or chemistry + mechanism of antibiotic resistance + determinant of antibiotic resistance + antibiotic molecule + antibiotic target replacement [Resistance Mechanism] + antibiotic target replacement protein + diaminopyrimidine antibiotic [Drug Class] + antibiotic resistant dihydrofolate reductase + trimethoprim [Antibiotic] |
| Parent Term(s) | 3 ontology terms | Show + confers_resistance_to_antibiotic trimethoprim [Antibiotic] + derives_from antibiotic sensitive dihydrofolate reductase + trimethoprim resistant dihydrofolate reductase dfr [AMR Gene Family] |
| Publications | Sandalli C, et al. 2010. Microbiol Immunol 54(3): 164-169. Prevalence of integrons and a new dfrA17 variant in Gram-negative bacilli which cause community-acquired infections. (PMID 20236427) |
Prevalence of dfrA17 among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 414 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).
| Species | NCBI Chromosome | NCBI Plasmid | NCBI WGS | NCBI GI | GRDI-AMR2 |
|---|---|---|---|---|---|
| Acinetobacter baumannii | 0.35% | 0% | 0.09% | 0% | 0% |
| Aeromonas hydrophila | 0% | 1.3% | 0.81% | 0% | 0% |
| Aeromonas veronii | 1.82% | 0% | 0.56% | 0% | 0% |
| Alcaligenes faecalis | 0% | 0% | 2.94% | 0% | 0% |
| Burkholderia cenocepacia | 0% | 0% | 1.54% | 0% | 0% |
| Citrobacter amalonaticus | 0% | 8.33% | 0% | 0% | 0% |
| Citrobacter freundii | 0% | 0% | 5.03% | 0% | 0% |
| Citrobacter portucalensis | 0% | 0% | 3.6% | 0% | 0% |
| Citrobacter werkmanii | 0% | 0% | 2.56% | 0% | 0% |
| Enterobacter asburiae | 0% | 0.28% | 0% | 0% | 0% |
| Enterobacter cloacae | 0% | 0% | 0.64% | 0% | 0% |
| Enterobacter hormaechei | 0% | 0.19% | 1.77% | 0% | 0% |
| Enterobacter kobei | 4.55% | 0% | 0% | 0% | 0% |
| Escherichia coli | 1.69% | 2.37% | 12.69% | 0.26% | 1.46% |
| Escherichia fergusonii | 0% | 0.36% | 9.78% | 0% | 0% |
| Klebsiella aerogenes | 0% | 1.09% | 0.85% | 0% | 0% |
| Klebsiella michiganensis | 9.68% | 0% | 1.33% | 0% | 0% |
| Klebsiella oxytoca | 0% | 0% | 3.78% | 0% | 0% |
| Klebsiella pneumoniae | 0.06% | 0.14% | 1.09% | 0.95% | 0% |
| Klebsiella quasipneumoniae | 0% | 0% | 0.66% | 0% | 0% |
| Laribacter hongkongensis | 0% | 0% | 0% | 50% | 0% |
| Morganella morganii | 5.77% | 0% | 8.59% | 7.69% | 0% |
| Pasteurella multocida | 0% | 0% | 0.37% | 0% | 0% |
| Proteus mirabilis | 11.01% | 1.25% | 8.42% | 18.52% | 0% |
| Providencia alcalifaciens | 9.09% | 0% | 0% | 0% | 0% |
| Providencia rettgeri | 0% | 2.7% | 0.64% | 0% | 0% |
| Salmonella enterica | 0.5% | 0.93% | 0.83% | 0.99% | 0% |
| Shigella boydii | 0% | 0% | 6.67% | 0% | 0% |
| Shigella dysenteriae | 0% | 0% | 3.33% | 0% | 0% |
| Shigella flexneri | 7% | 2.01% | 7.3% | 0% | 0% |
| Shigella sonnei | 0% | 4.85% | 1.46% | 4.76% | 0% |
| Vibrio parahaemolyticus | 0% | 0% | 0.1% | 0% | 0% |
| Yersinia enterocolitica | 0% | 0% | 0.45% | 0% | 0% |
Model Type: protein homolog model
Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.
Bit-score Cut-off (blastP): 300
| Curator | Description | Most Recent Edit |
|---|