| Accession | ARO:3003019 |
| CARD Short Name | dfrA23 |
| Definition | dfrA23 is an integron-encoded dihydrofolate reductase found in Salmonella enterica. |
| AMR Gene Family | trimethoprim resistant dihydrofolate reductase dfr |
| Drug Class | diaminopyrimidine antibiotic |
| Resistance Mechanism | antibiotic target replacement |
| Resistomes with Perfect Matches | Acinetobacter baumanniiwgs, Citrobacter freundiiwgs, Citrobacter werkmaniiwgs, Enterobacter hormaecheiwgs, Escherichia colip+wgs, Klebsiella pneumoniaep+wgs, Providencia rettgeriwgs, Pseudomonas aeruginosawgs, Salmonella entericag+p+wgs, Serratia marcescenswgs, Vibrio choleraewgs, Vibrio parahaemolyticuswgs |
| Resistomes with Sequence Variants | Acinetobacter baumanniiwgs, Citrobacter freundiiwgs, Citrobacter werkmaniiwgs, Enterobacter hormaecheiwgs, Escherichia colip+wgs, Klebsiella pneumoniaep+wgs, Providencia rettgeriwgs, Pseudomonas aeruginosawgs, Salmonella entericag+p+wgs, Serratia marcescenswgs, Vibrio choleraewgs, Vibrio parahaemolyticuswgs |
| Classification | 9 ontology terms | Show + process or component of antibiotic biology or chemistry + mechanism of antibiotic resistance + determinant of antibiotic resistance + antibiotic target replacement [Resistance Mechanism] + antibiotic molecule + diaminopyrimidine antibiotic [Drug Class] + antibiotic target replacement protein + trimethoprim [Antibiotic] + antibiotic resistant dihydrofolate reductase |
| Parent Term(s) | 3 ontology terms | Show + trimethoprim resistant dihydrofolate reductase dfr [AMR Gene Family] + derives_from antibiotic sensitive dihydrofolate reductase + confers_resistance_to_antibiotic trimethoprim [Antibiotic] |
| Publications | Villa L, et al. 2005. Antimicrob Agents Chemother 49(3): 1194-1197. Integrons and transposons on the Salmonella enterica serovar typhimurium virulence plasmid. (PMID 15728925) |
Prevalence of dfrA23 among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 413 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).
| Species | NCBI Chromosome | NCBI Plasmid | NCBI WGS | NCBI GI |
|---|---|---|---|---|
| Acinetobacter baumannii | 0% | 0% | 0.01% | 0% |
| Citrobacter freundii | 0% | 0% | 0.19% | 0% |
| Citrobacter werkmanii | 0% | 0% | 2.56% | 0% |
| Enterobacter hormaechei | 0% | 0% | 0.09% | 0% |
| Escherichia coli | 0% | 0.03% | 0.04% | 0% |
| Klebsiella pneumoniae | 0% | 0.1% | 0.09% | 0% |
| Providencia rettgeri | 0% | 0% | 1.27% | 0% |
| Pseudomonas aeruginosa | 0% | 0% | 0.01% | 0% |
| Salmonella enterica | 0.06% | 0.44% | 0.53% | 0% |
| Serratia marcescens | 0% | 0% | 0.13% | 0% |
| Vibrio cholerae | 0% | 0% | 0.77% | 0% |
| Vibrio parahaemolyticus | 0% | 0% | 0.1% | 0% |
Model Type: protein homolog model
Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.
Bit-score Cut-off (blastP): 300