folate synthesis enzyme targeted by antibiotic

Accession ARO:3000714
DefinitionEnzymes in the folate synthesis pathway are targeted by two main classes of antibiotics: sulfonamides and diaminopyrimidines. Inhibition of these enzymes block the production of key precursors for nucleotides and amino acids.
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Hitchings GH and Burchall JJ. 1969. Adv Enzymol Relat Areas Mol Biol 27: 417-468. Inhibition of folate biosynthesis and function as a basis for chemotherapy. (PMID 4387360)