antibiotic sensitive dihydropteroate synthase

Accession ARO:3000744
DefinitionDihydropteroate synthase catalyzes the conversion of p-aminobenzoic acid to dihydropteroic acid as part of the tetrahydrofolic acid biosynthetic pathway. Tetrahydrofolic acid is essential for folate synthesis, and a precursor of many nucleotides and amino acids. Inhibiting dihydropteroate leads to slow cell death, as bacteria can survive on existing folate storages for a few generations.
Drug Classsulfonamide antibiotic, sulfone antibiotic
Classification2 ontology terms | Show
Parent Term(s)13 ontology terms | Show
+ folate synthesis enzyme targeted by antibiotic
+ targeted_by sulfonamide antibiotic [Drug Class]
+ targeted_by_antibiotic mafenide [Antibiotic]
+ targeted_by_antibiotic sulfacetamide [Antibiotic]
+ targeted_by_antibiotic sulfadiazine [Antibiotic]
+ targeted_by_antibiotic sulfadimidine [Antibiotic]
+ targeted_by_antibiotic sulfadoxine [Antibiotic]
+ targeted_by_antibiotic sulfamethizole [Antibiotic]
+ targeted_by_antibiotic sulfamethoxazole [Antibiotic]
+ targeted_by_antibiotic sulfasalazine [Antibiotic]
+ targeted_by_antibiotic sulfisoxazole [Antibiotic]
+ targeted_by sulfone antibiotic [Drug Class]
+ targeted_by_antibiotic dapsone [Antibiotic]
5 ontology terms | Show
+ sul1 derives_from
+ sul2 derives_from
+ sul3 derives_from
+ antibiotic resistant folP derives_from
+ dapsone resistant dihydropteroate synthase folP [AMR Gene Family] derives_from

Bermingham A and Derrick JP. 2002. Bioessays 24(7): 637-648. The folic acid biosynthesis pathway in bacteria: evaluation of potential for antibacterial drug discovery. (PMID 12111724)