sulfamethoxazole [Antibiotic]

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Accession ARO:3000329
DefinitionSulfamethoxazole is a sulfonamide antibiotic usually taken with trimethoprim, a diaminopyrimidine antibiotic. Sulfamethoxazole inhibits dihydropteroate synthase, essential to tetrahydrofolic acid biosynthesis. This pathway generates compounds used in the synthesis of many amino acids and nucleotides.
Drug Classsulfonamide antibiotic
Classification2 ontology terms | Show
Parent Term(s)1 ontology terms | Show
+ sulfonamide antibiotic [Drug Class]
Sub-Term(s)
7 ontology terms | Show
+ antibiotic sensitive dihydropteroate synthase targeted_by_antibiotic
+ sul1 confers_resistance_to_antibiotic
+ sul2 confers_resistance_to_antibiotic
+ sul3 confers_resistance_to_antibiotic
+ Escherichia coli folP with mutation conferring resistance to sulfonamides confers_resistance_to_antibiotic
+ Streptococcus pyogenes folP with mutation conferring resistance to sulfonamides confers_resistance_to_antibiotic
+ trimethoprim-sulfamethoxazole [Antibiotic] has_part
Publications

Bushby SR. 1975. Can Med Assoc J 112(13): 63-66. Synergy of trimethoprim-sulfamethoxazole. (PMID 1093654)