| Accession | ARO:3004361 |
| CARD Short Name | sul4 |
| Definition | sul4 is a dihydropteroate synthase gene and mobile sulfonamide resistance gene shown to confer resistance when expressed in E. coli. |
| AMR Gene Family | sulfonamide resistant sul |
| Drug Class | sulfonamide antibiotic |
| Resistance Mechanism | antibiotic target replacement |
| Resistomes with Perfect Matches | Sphingobium yanoikuyaep |
| Resistomes with Sequence Variants | Aeromonas caviaewgs, Salmonella entericag, Sphingobium yanoikuyaep |
| Classification | 7 ontology terms | Show |
| Parent Term(s) | 2 ontology terms | Show + confers_resistance_to_antibiotic sulfamethoxazole [Antibiotic] + sulfonamide resistant sul [AMR Gene Family] |
| Publications | Razavi M, et al. 2017. Microbiome 5(1):160 Discovery of the fourth mobile sulfonamide resistance gene. (PMID 29246178) |
Prevalence of sul4 among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 413 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).
| Species | NCBI Chromosome | NCBI Plasmid | NCBI WGS | NCBI GI |
|---|---|---|---|---|
| Aeromonas caviae | 0% | 0% | 0.54% | 0% |
| Salmonella enterica | 0.06% | 0% | 0% | 0% |
| Sphingobium yanoikuyae | 0% | 4% | 0% | 0% |
Model Type: protein homolog model
Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.
Bit-score Cut-off (blastP): 500
Type of Antibiotic Resistance: Acquired