sulfonamide antibiotic [Drug Class]

Accession ARO:3000282
DefinitionSulfonamides are broad spectrum, synthetic antibiotics that contain the sulfonamide group. Sulfonamides inhibit dihydropteroate synthase, which catalyzes the conversion of p-aminobenzoic acid to dihydropteroic acid as part of the tetrahydrofolic acid biosynthetic pathway. Tetrahydrofolic acid is essential for folate synthesis, a precursor of many nucleotides and amino acids. Many sulfamides are taken with trimethoprim, an inhibitor of dihydrofolate reductase, also disturbing the trihydrofolic acid synthesis pathway.
Classification1 ontology terms | Show
Parent Term(s)1 ontology terms | Show
Sub-Term(s)
15 ontology terms | Show
+ sulfadiazine [Antibiotic]
+ sulfadimidine [Antibiotic]
+ sulfadoxine [Antibiotic]
+ sulfamethoxazole [Antibiotic]
+ sulfisoxazole [Antibiotic]
+ sulfacetamide [Antibiotic]
+ mafenide [Antibiotic]
+ sulfasalazine [Antibiotic]
+ sulfamethizole [Antibiotic]
+ determinant of sulfonamide resistance confers_resistance_to_drug_class
+ sulfonamide resistant dihydropteroate synthase folP [AMR Gene Family] confers_resistance_to_drug_class
+ sulfonamide resistant sul [AMR Gene Family] confers_resistance_to_drug_class
+ MexAB-OprM confers_resistance_to_drug_class
+ MexAB-OprM with MexR mutations confers resistance to multiple antibiotics confers_resistance_to_drug_class
+ antibiotic sensitive dihydropteroate synthase targeted_by
Publications

Antunes P, et al. 2005. Antimicrob Agents Chemother 49(2): 836-839. Dissemination of sulfonamide resistance genes (sul1, sul2, and sul3) in Portuguese Salmonella enterica strains and relation with integrons. (PMID 15673783)