Ontology | CARD's Antibiotic Resistance Ontology |
Accession | ARO:3000698 |
Synonym(s) | salicylazosulfapyridine |
Definition | Sulfasalazine is a derivative of the early sulfonamide sulfapyridine (salicylazosulfapyridine). It was developed to increase water solubility and is taken orally for ulcerative colitis. |
SMILES | O=C(O)c1cc(/N=N/c2ccc(S(=O)(=O)Nc3ccccn3)cc2)ccc1O |
PubChem | 5339 |
ChEBI | 9334 |
CAS | 599-79-1 |
ChEMBL | CHEMBL421 |
Drug Class | sulfonamide antibiotic |
Classification | 2 ontology terms | Show |
Parent Term(s) | 1 ontology terms | Show + sulfonamide antibiotic [Drug Class] |
Sub-Term(s) | 6 ontology terms | Show + antibiotic sensitive dihydropteroate synthase targeted_by_antibiotic + sul1 confers_resistance_to_antibiotic + sul2 confers_resistance_to_antibiotic + sul3 confers_resistance_to_antibiotic + Escherichia coli folP with mutation conferring resistance to sulfonamides confers_resistance_to_antibiotic + Streptococcus pyogenes folP with mutation conferring resistance to sulfonamides confers_resistance_to_antibiotic |
Publications | Selhub J, et al. 1978. J Clin Invest 61(1): 221-224. Inhibition of folate enzymes by sulfasalazine. (PMID 22555) |
Curator | Description | Most Recent Edit |
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