| Accession | ARO:3000413 |
| CARD Short Name | sul3 |
| Definition | Sul3 is a sulfonamide resistant dihydropteroate synthase similar to Sul1 and Sul2. Its resistance gene was found encoded in E. coli plasmid DNA of sulfonamide resistant isolates. |
| AMR Gene Family | sulfonamide resistant sul |
| Drug Class | sulfonamide antibiotic |
| Resistance Mechanism | antibiotic target replacement |
| Resistomes with Perfect Matches | Acinetobacter indicusp, Avibacterium paragallinarumg, Citrobacter freundiiwgs, Citrobacter werkmaniiwgs, Citrobacter youngaewgs, Enterobacter asburiaewgs, Enterobacter cloacaep+wgs, Enterobacter hormaecheip+wgs, Enterobacter roggenkampiip, Escherichia albertiip+wgs, Escherichia colig+p+wgs+gi, Escherichia fergusoniip+wgs, Klebsiella aerogeneswgs, Klebsiella michiganensisp, Klebsiella oxytocap, Klebsiella pneumoniaeg+p+wgs, Klebsiella quasipneumoniaewgs, Morganella morganiig+wgs+gi, Pasteurella multocidag+gi, Proteus mirabilisg+p+wgs+gi, Providencia rettgeriwgs, Salmonella entericag+p+wgs+gi, Shigella boydiiwgs, Shigella dysenteriaeg, Shigella flexnerig+p+wgs, Shigella sonneiwgs, Yersinia enterocoliticawgs |
| Resistomes with Sequence Variants | Acinetobacter indicusp, Avibacterium paragallinarumg, Citrobacter freundiiwgs, Citrobacter werkmaniiwgs, Citrobacter youngaewgs, Enterobacter asburiaewgs, Enterobacter cloacaep+wgs, Enterobacter hormaecheip+wgs, Enterobacter roggenkampiip, Escherichia albertiip+wgs, Escherichia colig+p+wgs+gi, Escherichia fergusoniip+wgs, Klebsiella aerogeneswgs, Klebsiella michiganensisp, Klebsiella oxytocap, Klebsiella pneumoniaeg+p+wgs, Klebsiella quasipneumoniaewgs, Morganella morganiig+wgs+gi, Pasteurella multocidag+gi, Proteus mirabilisg+p+wgs+gi, Providencia rettgeriwgs, Salmonella entericag+p+wgs+gi, Shigella boydiiwgs, Shigella dysenteriaeg, Shigella flexnerig+p+wgs, Shigella sonneiwgs, Yersinia enterocoliticawgs |
| Classification | 7 ontology terms | Show |
| Parent Term(s) | 11 ontology terms | Show + confers_resistance_to_antibiotic sulfadiazine [Antibiotic] + confers_resistance_to_antibiotic sulfadimidine [Antibiotic] + confers_resistance_to_antibiotic sulfadoxine [Antibiotic] + confers_resistance_to_antibiotic sulfamethoxazole [Antibiotic] + confers_resistance_to_antibiotic sulfisoxazole [Antibiotic] + confers_resistance_to_antibiotic sulfacetamide [Antibiotic] + confers_resistance_to_antibiotic mafenide [Antibiotic] + confers_resistance_to_antibiotic sulfasalazine [Antibiotic] + confers_resistance_to_antibiotic sulfamethizole [Antibiotic] + derives_from antibiotic sensitive dihydropteroate synthase + sulfonamide resistant sul [AMR Gene Family] |
| Publications | Perreten V and Boerlin P. 2003. Antimicrob Agents Chemother 47(3): 1169-1172. A new sulfonamide resistance gene (sul3) in Escherichia coli is widespread in the pig population of Switzerland. (PMID 12604565) |
Prevalence of sul3 among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 413 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).
| Species | NCBI Chromosome | NCBI Plasmid | NCBI WGS | NCBI GI |
|---|---|---|---|---|
| Acinetobacter indicus | 0% | 1.89% | 0% | 0% |
| Avibacterium paragallinarum | 6.25% | 0% | 0% | 0% |
| Citrobacter freundii | 0% | 0% | 0.39% | 0% |
| Citrobacter werkmanii | 0% | 0% | 2.56% | 0% |
| Citrobacter youngae | 0% | 0% | 12.5% | 0% |
| Enterobacter asburiae | 0% | 0% | 0.4% | 0% |
| Enterobacter cloacae | 0% | 0.56% | 0.96% | 0% |
| Enterobacter hormaechei | 0% | 0.06% | 0.3% | 0% |
| Enterobacter roggenkampii | 0% | 0.48% | 0% | 0% |
| Escherichia albertii | 0% | 0.56% | 2.58% | 0% |
| Escherichia coli | 0.45% | 1.71% | 4.66% | 0.89% |
| Escherichia fergusonii | 0% | 3.91% | 10.87% | 0% |
| Klebsiella aerogenes | 0% | 0% | 0.56% | 0% |
| Klebsiella michiganensis | 0% | 0.57% | 0% | 0% |
| Klebsiella oxytoca | 0% | 1.37% | 0% | 0% |
| Klebsiella pneumoniae | 0.06% | 0.76% | 2.57% | 0% |
| Klebsiella quasipneumoniae | 0% | 0% | 1.18% | 0% |
| Morganella morganii | 1.92% | 0% | 1.23% | 7.69% |
| Pasteurella multocida | 0.71% | 0% | 0% | 16.67% |
| Proteus mirabilis | 7.34% | 1.25% | 2.81% | 3.7% |
| Providencia rettgeri | 0% | 0% | 0.64% | 0% |
| Salmonella enterica | 1.89% | 5.69% | 1.71% | 2.65% |
| Shigella boydii | 0% | 0% | 6.67% | 0% |
| Shigella dysenteriae | 14.29% | 0% | 0% | 0% |
| Shigella flexneri | 1% | 6.02% | 0.16% | 0% |
| Shigella sonnei | 0% | 0% | 0.73% | 0% |
| Yersinia enterocolitica | 0% | 0% | 0.91% | 0% |
Model Type: protein homolog model
Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.
Bit-score Cut-off (blastP): 500