sulfisoxazole [Antibiotic]

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Ontology CARD's Antibiotic Resistance Ontology
Accession ARO:3000330
DefinitionSulfisoxazole is an inhibitor of dihydropteroate synthase, interfering with the tetrahydrofolic biosynthesis pathway. Tetrahydrofolic acid is essential for folate synthesis, a precursor to many nucleotides and amino acids.
SMILESCc1noc(NS(=O)(=O)c2ccc(N)cc2)c1C
PubChem5344
ChEMBLCHEMBL453
ChEBI102484
CAS127-69-5
Drug Classsulfonamide antibiotic
Classification2 ontology terms | Show
Parent Term(s)1 ontology terms | Show
+ sulfonamide antibiotic [Drug Class]
Sub-Term(s)
7 ontology terms | Show
+ antibiotic sensitive dihydropteroate synthase targeted_by_antibiotic
+ sul1 confers_resistance_to_antibiotic
+ sul2 confers_resistance_to_antibiotic
+ sul3 confers_resistance_to_antibiotic
+ Escherichia coli folP with mutation conferring resistance to sulfonamides confers_resistance_to_antibiotic
+ Streptococcus pyogenes folP with mutation conferring resistance to sulfonamides confers_resistance_to_antibiotic
+ Neisseria gonorrhoeae folP with mutation conferring resistance to sulfonamides confers_resistance_to_antibiotic
Publications

Slywka GW, et al. 1976. J Pharm Sci 65(10): 1494-1498. Bioavailability of 11 sulfisoxazole products in humans. (PMID 978409)

Curator Acknowledgements
Curator Description Most Recent Edit