antibiotic resistant folP

Accession ARO:3000226
Synonym(s)dihydropteroate synthase
DefinitionPoint mutations in dihydropteroate synthase folP prevent sulfonamide antibiotics from inhibiting its role in folate synthesis, thus conferring sulfonamide resistance.
Resistance Mechanismantibiotic target alteration
Classification5 ontology terms | Show
Parent Term(s)2 ontology terms | Show
2 ontology terms | Show

Nakata N, et al. 2011. Antimicrob Agents Chemother 55(2): 762-766. Mutation analysis of the Mycobacterium leprae folP1 gene and dapsone resistance. (PMID 21115799)

Fermer C and Swedberg G. 1997. J Bacteriol 179(3): 831-837. Adaptation to sulfonamide resistance in Neisseria meningitidis may have required compensatory changes to retain enzyme function: kinetic analysis of dihydropteroate synthases from N. meningitidis expressed in a knockout mutant of Escherichia coli. (PMID 9006040)

Vedantam G, et al. 1998. Antimicrob Agents Chemother 42(1): 88-93. Characterization of mutations contributing to sulfathiazole resistance in Escherichia coli. (PMID 9449266)

Swedberg G, et al. 1998. Antimicrob Agents Chemother 42(5): 1062-1067. Sulfonamide resistance in Streptococcus pyogenes is associated with differences in the amino acid sequence of its chromosomal dihydropteroate synthase. (PMID 9593127)

Dallas WS, et al. 1992. J Bacteriol 174(18): 5961-5970. Cloning, sequencing, and enhanced expression of the dihydropteroate synthase gene of Escherichia coli MC4100. (PMID 1522070)