| Ontology | CARD's Antibiotic Resistance Ontology |
| Accession | ARO:3000226 |
| Synonym(s) | dihydropteroate synthase |
| Definition | Point mutations in dihydropteroate synthase folP prevent sulfonamide antibiotics from inhibiting its role in folate synthesis, thus conferring sulfonamide resistance. |
| Drug Class | sulfone antibiotic, sulfonamide antibiotic |
| Resistance Mechanism | antibiotic target alteration |
| Classification | 20 ontology terms | Show + process or component of antibiotic biology or chemistry + antibiotic molecule + mechanism of antibiotic resistance + sulfone antibiotic [Drug Class] + antibiotic target + sulfonamide antibiotic [Drug Class] + antibiotic target alteration [Resistance Mechanism] + dapsone [Antibiotic] + folate synthesis enzyme targeted by antibiotic + sulfamethizole [Antibiotic] + sulfasalazine [Antibiotic] + mafenide [Antibiotic] + sulfacetamide [Antibiotic] + sulfisoxazole [Antibiotic] + sulfamethoxazole [Antibiotic] + sulfadoxine [Antibiotic] + sulfadimidine [Antibiotic] + sulfadiazine [Antibiotic] + mutation conferring antibiotic resistance + determinant of antibiotic resistance |
| Parent Term(s) | 2 ontology terms | Show |
| Sub-Term(s) | 2 ontology terms | Show + dapsone resistant dihydropteroate synthase folP [AMR Gene Family] + sulfonamide resistant dihydropteroate synthase folP [AMR Gene Family] |
| Publications | Nakata N, et al. 2011. Antimicrob Agents Chemother 55(2): 762-766. Mutation analysis of the Mycobacterium leprae folP1 gene and dapsone resistance. (PMID 21115799) Fermer C and Swedberg G. 1997. J Bacteriol 179(3): 831-837. Adaptation to sulfonamide resistance in Neisseria meningitidis may have required compensatory changes to retain enzyme function: kinetic analysis of dihydropteroate synthases from N. meningitidis expressed in a knockout mutant of Escherichia coli. (PMID 9006040) Vedantam G, et al. 1998. Antimicrob Agents Chemother 42(1): 88-93. Characterization of mutations contributing to sulfathiazole resistance in Escherichia coli. (PMID 9449266) Swedberg G, et al. 1998. Antimicrob Agents Chemother 42(5): 1062-1067. Sulfonamide resistance in Streptococcus pyogenes is associated with differences in the amino acid sequence of its chromosomal dihydropteroate synthase. (PMID 9593127) Dallas WS, et al. 1992. J Bacteriol 174(18): 5961-5970. Cloning, sequencing, and enhanced expression of the dihydropteroate synthase gene of Escherichia coli MC4100. (PMID 1522070) |
| Curator | Description | Most Recent Edit |
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