dapsone resistant dihydropteroate synthase folP [AMR Gene Family]

Accession ARO:3003388
DefinitionDapsone inhibits bacterial synthesis of dihydrofolic acid by competing with with para-aminobenzoate for the active site of dihydropteroate synthetase. Thus acts as a competitive inhibitor of folP. Point mutation within the folP gene results in lowered affinity of dapsone for folP.
Drug Classsulfone antibiotic
Resistance Mechanismantibiotic target alteration
Classification7 ontology terms | Show
Parent Term(s)3 ontology terms | Show
+ antibiotic resistant folP
+ confers_resistance_to_drug_class sulfone antibiotic [Drug Class]
+ derives_from antibiotic sensitive dihydropteroate synthase
1 ontology terms | Show