| Accession | ARO:3003389 |
| CARD Short Name | Mlep_folP_DAO |
| Definition | Dapsone inhibits bacterial synthesis of dihydrofolic acid by competing with with para-aminobenzoate for the active site of dihydropteroate synthetase. Point mutation within the Mycobacterium leprae folP gene results in lowered affinity of dapsone for folP. |
| AMR Gene Family | dapsone resistant dihydropteroate synthase folP |
| Drug Class | sulfone antibiotic |
| Resistance Mechanism | antibiotic target alteration |
| Classification | 9 ontology terms | Show + process or component of antibiotic biology or chemistry + mechanism of antibiotic resistance + antibiotic target alteration [Resistance Mechanism] + mutation conferring antibiotic resistance + determinant of antibiotic resistance + antibiotic resistant gene variant or mutant + antibiotic molecule + sulfone antibiotic [Drug Class] + antibiotic resistant folP |
| Parent Term(s) | 2 ontology terms | Show + dapsone resistant dihydropteroate synthase folP [AMR Gene Family] + confers_resistance_to_antibiotic dapsone [Antibiotic] |
| Publications | Nakata N, et al. 2011. Antimicrob Agents Chemother 55(2): 762-766. Mutation analysis of the Mycobacterium leprae folP1 gene and dapsone resistance. (PMID 21115799) You EY, et al. 2004. J Infect 50(1): 6-11. Mutations in genes related to drug resistance in Mycobacterium leprae isolates from leprosy patients in Korea. (PMID 15603834) Maeda S, et al. 2001. Antimicrob. Agents Chemother. 45(12):3635-9 Multidrug resistant Mycobacterium leprae from patients with leprosy. (PMID 11709358) |
Prevalence of Mycobacterium leprae folP with mutation conferring resistance to dapsone among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 413 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).
| Species | NCBI Chromosome | NCBI Plasmid | NCBI WGS | NCBI GI |
|---|---|---|---|---|
| No prevalence data | ||||
Model Type: protein variant model
Model Definition: Protein Variant Models (PVM) perform a similar search as Protein Homolog Models (PHM), i.e. detect protein sequences based on their similarity to a curated reference sequence, but secondarily screen query sequences for curated sets of mutations to differentiate them from antibiotic susceptible wild-type alleles. PVMs are designed to detect AMR acquired via mutation of house-keeping genes or antibiotic targets, e.g. a mutated gyrase resistant to aminocoumarin antibiotics. PVMs include a protein reference sequence (often from antibiotic susceptible wild-type alleles), a curated bit-score cut-off, and mapped resistance variants. Mapped resistance variants may include any or all of single point mutations, insertions, or deletions curated from the scientific literature. A Strict RGI match has a BLASTP bit-score above the curated BLASTP cutoff value and contains at least one curated mutation from amongst the mapped resistance variants, while a Loose RGI match has a bit-score less than the curated BLASTP bit-score cut-off but still contains at least one curated mutation from amongst the mapped resistance variants.
Bit-score Cut-off (blastP): 500
Legend:
Published Variants:
| PMID: 21115799 | V48G V48A V48F T53I T53A T53N T53P R54G P55L P55H P55A P55T |
| PMID: 15603834 | P55S P55R |
| PMID: 11709358 | T53I T53A P55L |