dfrI

Accession ARO:3004645
DefinitiondfrI is a dihydrofolate reductase that is resistant to trimethoprim.
AMR Gene Familytrimethoprim resistant dihydrofolate reductase dfr
Drug Classdiaminopyrimidine antibiotic
Resistance Mechanismantibiotic target replacement
ResistomesSalmonella entericawgs
Classification10 ontology terms | Show
Parent Term(s)2 ontology terms | Show
+ confers_resistance_to_drug_class trimethoprim [Antibiotic]
+ trimethoprim resistant dihydrofolate reductase dfr [AMR Gene Family]
Publications

Welch TJ, et al. 2007. PLoS ONE 2(3):e309 Multiple antimicrobial resistance in plague: an emerging public health risk. (PMID 17375195)

Resistomes

Prevalence of dfrI among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI for 82 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).

Prevalence: protein homolog model (view sequences)

SpeciesNCBI ChromosomeNCBI PlasmidNCBI WGS
Salmonella enterica0%0%0.03%
Show Perfect Only


Detection Models

Model Type: protein homolog model

Model Definition: The protein homolog model is an AMR detection model. Protein homolog models detect a protein sequence based on its similarity to a curated reference sequence. A protein homolog model has only one parameter: a curated BLASTP bitscore cutoff for determining the strength of a match. Protein homolog model matches to reference sequences are categorized on three criteria: perfect, strict and loose. A perfect match is 100% identical to the reference sequence along its entire length; a strict match is not identical but the bitscore of the matched sequence is greater than the curated BLASTP bitscore cutoff. Loose matches are other sequences with a match bitscore less than the curated BLASTP bitscore.

Bit-score Cut-off (blastP): 350


>gb|ABO40886.1|-|dfrI [Yersinia ruckeri]
MNQNRDDHNRAADREKTAEKRGENQCIISLILAMADNGTIGDKNALPWHLPNDLQFLKKSTMGKPIVMGRKTYQSIGRPLPGRTNVVISR
SLEKEALPGCLIYSDLSVAIAALKKEPEVEEIMIMGGAQIYRAALPMMDRLYLTHVHANIEGDTQMPPFDFSHATLIFEEKHFKDEKNRY
DYTFEIWDFKK


>gb|CP000602.1|-|93827-94402|dfrI [Yersinia ruckeri]
ATGAATCAAAACAGAGACGACCATAATCGTGCAGCAGATAGAGAAAAAACAGCAGAGAAAAGAGGAGAAAACCAGTGCATCATCTCCCTT
ATTTTAGCAATGGCAGATAATGGCACAATTGGTGATAAAAATGCCCTACCATGGCATCTTCCTAATGATCTGCAATTTTTAAAAAAGAGC
ACTATGGGAAAGCCGATTGTTATGGGCCGAAAAACTTACCAATCGATTGGCCGGCCACTTCCCGGCAGAACCAATGTAGTAATCTCACGC
TCTTTAGAGAAGGAGGCTCTCCCCGGATGCTTAATCTATTCCGATCTCTCAGTTGCGATAGCGGCACTTAAAAAAGAGCCCGAGGTTGAA
GAGATTATGATTATGGGGGGCGCGCAGATCTATAGAGCAGCTCTTCCTATGATGGATCGACTCTATCTTACCCATGTACATGCCAATATC
GAAGGGGATACCCAGATGCCCCCCTTTGATTTTAGCCATGCAACCCTCATCTTTGAAGAGAAGCATTTTAAAGATGAGAAGAATCGATAT
GATTACACCTTTGAGATTTGGGACTTCAAAAAATAG