MexEF-OprN with MexT mutation conferring resistance to chloramphenicol, ciprofloxacin, and trimethoprim

Accession ARO:3004066
DefinitionThe MexEF–OprN efflux pump in P. aeruginosa is overexpressed with MexT mutation conferring resistance to chloramphenicol and ciprofloxacin
AMR Gene Familyresistance-nodulation-cell division (RND) antibiotic efflux pump
Drug Classtetracycline antibiotic, triclosan, fluoroquinolone antibiotic, diaminopyrimidine antibiotic, monobactam, antibacterial free fatty acids, phenicol antibiotic, acridine dye, penam, aminoglycoside antibiotic, glycylcycline, macrolide antibiotic, carbapenem, aminocoumarin antibiotic
Resistance Mechanismantibiotic efflux
Efflux Componentefflux pump complex or subunit conferring antibiotic resistance
Classification25 ontology terms | Show
Parent Term(s)4 ontology terms | Show
+ confers_resistance_to_antibiotic ciprofloxacin [Antibiotic]
+ confers_resistance_to_antibiotic trimethoprim [Antibiotic]
+ confers_resistance_to_antibiotic chloramphenicol [Antibiotic]
+ MexEF-OprN
Sub-Term(s)
4 ontology terms | Show
+ MexE part_of
+ MexF part_of
+ OprN part_of
+ MexT part_of
Publications

Richardot C, et al. 2016. Antimicrob. Agents Chemother. 60(4):2302-10 Amino Acid Substitutions Account for Most MexS Alterations in Clinical nfxC Mutants of Pseudomonas aeruginosa. (PMID 26833155)

Resistomes

Prevalence of MexEF-OprN with MexT mutation conferring resistance to chloramphenicol, ciprofloxacin, and trimethoprim among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI for 82 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).

Prevalence: efflux pump system meta-model

SpeciesNCBI ChromosomeNCBI PlasmidNCBI WGS
No prevalence data


Detection Models

Model Name: MexEF-OprN with MexT mutation conferring resistance to chloramphenicol, ciprofloxacin, and trimethoprim

Model Description: The MexEF–OprN efflux pump in P. aeruginosa is overexpressed with MexT mutation conferring resistance to chloramphenicol and ciprofloxacin

OprNMexTMexEMexF