MexE

Accession ARO:3000803
DefinitionMexE is the membrane fusion protein of the MexEF-OprN multidrug efflux complex.
AMR Gene Familyresistance-nodulation-cell division (RND) antibiotic efflux pump
Drug Classtetracycline antibiotic, macrolide antibiotic, phenicol antibiotic, diaminopyrimidine antibiotic, carbapenem, fluoroquinolone antibiotic, penam, triclosan, antibacterial free fatty acids, glycylcycline, aminocoumarin antibiotic, aminoglycoside antibiotic, monobactam, acridine dye
Resistance Mechanismantibiotic efflux
Efflux Componentefflux pump complex or subunit conferring antibiotic resistance
ResistomesPseudomonas fluorescensg
Classification28 ontology terms | Show
Parent Term(s)5 ontology terms | Show
Publications

Kohler T, et al. 1999. J Bacteriol 181(20): 6300-6305. Characterization of MexT, the regulator of the MexE-MexF-OprN multidrug efflux system of Pseudomonas aeruginosa. (PMID 10515918)

Resistomes

Prevalence of MexE among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI for 82 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).

Prevalence: protein homolog model (view sequences)

SpeciesNCBI ChromosomeNCBI PlasmidNCBI WGS
Enterobacter cloacae0%0%0%
Pseudomonas aeruginosa0%0%0%
Pseudomonas fluorescens3.7%0%0%
Stenotrophomonas maltophilia0%0%0%
Show Perfect Only


Detection Models

Model Type: protein homolog model

Model Definition: The protein homolog model is an AMR detection model. Protein homolog models detect a protein sequence based on its similarity to a curated reference sequence. A protein homolog model has only one parameter: a curated BLASTP bitscore cutoff for determining the strength of a match. Protein homolog model matches to reference sequences are categorized on three criteria: perfect, strict and loose. A perfect match is 100% identical to the reference sequence along its entire length; a strict match is not identical but the bitscore of the matched sequence is greater than the curated BLASTP bitscore cutoff. Loose matches are other sequences with a match bitscore less than the curated BLASTP bitscore.

Bit-score Cut-off (blastP): 750


>gb|AAG05881.1|+|MexE [Pseudomonas aeruginosa PAO1]
MEQSSHFSWRYPLALAAVLVLSACGKAPETTQGMAAPKVSVAEVIEQPLNEWDEFTGRLEAPESVELRPRVSGYIDRVAFHEGALVKKGD
LLFQIDPRPFEAEVKRLEAQLQQARAAQARSVNEAQRGERLRASNAISAELADARTTAAQEAKAAVAATQAQLDAARLNLSFTRITAPID
GRVSRAEVTAGNLVNSGETLLTTLVSTDKVYAYFDADERVFLKYVELARQAGRDTRSESPVYLGLSSEDGNPHLGRLDFLDNQVNPRTGT
IRGRAVFDNAKGEFTPGLYVRLKLVGSKTYAATLIKDEAVGTDLGKKFVLVLDGDNKTVYRTVEMGPKLEGLRIVRSGLSKGDRIVVNGL
QRVRPGMQVDPQKVEMASADTLATLARLRQSVGDSEPPKVAASKDNATRNEPRG


>gb|AE004091.2|+|2808743-2809987|MexE [Pseudomonas aeruginosa PAO1]
ATGGAACAGTCATCCCACTTCTCCTGGCGCTACCCCCTCGCACTCGCGGCCGTACTGGTCCTGAGCGCCTGCGGCAAGGCCCCGGAAACC
ACCCAAGGCATGGCGGCGCCCAAGGTCAGCGTCGCCGAAGTCATCGAACAACCGCTGAACGAGTGGGACGAATTCACCGGCCGCCTGGAG
GCCCCGGAGTCGGTGGAGCTGCGCCCGCGGGTGTCGGGCTACATCGACCGCGTGGCCTTCCATGAAGGCGCACTGGTGAAGAAAGGCGAC
CTGCTGTTCCAGATCGACCCGCGCCCGTTCGAGGCCGAGGTCAAGCGCCTCGAAGCCCAGCTGCAACAGGCCCGCGCGGCCCAGGCGCGG
AGCGTCAACGAAGCCCAGCGCGGCGAACGCCTGCGCGCCAGCAACGCGATCTCCGCGGAACTCGCCGACGCCCGCACCACCGCCGCCCAG
GAAGCCAAGGCGGCGGTCGCCGCGACCCAGGCGCAACTGGACGCGGCGCGCCTGAACCTGAGCTTCACCCGGATCACCGCGCCGATCGAC
GGTCGCGTCAGCCGCGCCGAGGTCACCGCCGGCAACCTGGTCAACTCCGGGGAGACCCTGCTCACCACCCTGGTCAGCACCGACAAGGTC
TACGCCTACTTCGACGCCGACGAGCGCGTGTTCCTCAAGTACGTCGAGCTGGCCCGCCAGGCCGGTCGCGACACGCGCAGCGAGAGCCCG
GTGTACCTCGGCCTGAGCAGCGAGGACGGCAACCCGCACCTGGGCCGGCTGGACTTCCTCGACAACCAGGTCAACCCGCGTACCGGCACC
ATCCGCGGCCGCGCCGTGTTCGACAACGCCAAGGGCGAGTTCACCCCGGGCCTCTACGTGCGCCTGAAGCTGGTCGGCAGCAAGACCTAC
GCCGCCACCCTGATCAAGGACGAAGCGGTCGGCACCGACCTGGGCAAGAAGTTCGTGCTGGTCCTGGATGGCGACAACAAGACCGTCTAC
CGCACCGTCGAGATGGGACCGAAGCTGGAGGGCCTGCGCATCGTCCGCAGCGGCCTGAGCAAGGGCGACCGGATCGTCGTGAATGGCCTG
CAGCGGGTCCGCCCGGGCATGCAGGTGGATCCGCAGAAGGTCGAGATGGCCAGCGCCGACACCCTGGCCACCCTCGCGCGCCTGCGGCAG
TCGGTCGGCGACAGCGAACCACCGAAGGTGGCGGCGTCCAAGGACAACGCCACTCGCAACGAGCCGCGCGGCTGA