MexPQ-OpmE

Accession ARO:3003697
DefinitionMexPQ-OpmE multidrug efflux pump expressed in Pseudomonas aeruginosa. MexP is the membrane fusion protein; MexQ is the inner membrane transporter; and OpmE is the outer membrane channel.
AMR Gene Familyresistance-nodulation-cell division (RND) antibiotic efflux pump
Drug Classtetracycline antibiotic, macrolide antibiotic, phenicol antibiotic, triclosan, monobactam, diaminopyrimidine antibiotic, acridine dye, carbapenem, antibacterial free fatty acids, penam, aminocoumarin antibiotic, aminoglycoside antibiotic, fluoroquinolone antibiotic, glycylcycline
Resistance Mechanismantibiotic efflux
Efflux Componentefflux pump complex or subunit conferring antibiotic resistance
Classification22 ontology terms | Show
Parent Term(s)10 ontology terms | Show
+ resistance-nodulation-cell division (RND) antibiotic efflux pump [AMR Gene Family]
+ confers_resistance_to_antibiotic imipenem [Antibiotic]
+ confers_resistance_to_antibiotic tetracycline [Antibiotic]
+ confers_resistance_to_antibiotic erythromycin [Antibiotic]
+ confers_resistance_to_antibiotic kitasamycin [Antibiotic]
+ confers_resistance_to_antibiotic chloramphenicol [Antibiotic]
+ confers_resistance_to_antibiotic thiamphenicol [Antibiotic]
+ confers_resistance_to_antibiotic rokitamycin [Antibiotic]
+ confers_resistance_to_antibiotic acriflavine [Antibiotic]
+ confers_resistance_to_antibiotic trimethoprim [Antibiotic]
Sub-Term(s)
3 ontology terms | Show
+ mexP part_of
+ mexQ part_of
+ opmE part_of
Publications

Mima T, et al. 2005. Microbiol. Immunol. 49(11):999-1002 Gene cloning and properties of the RND-type multidrug efflux pumps MexPQ-OpmE and MexMN-OprM from Pseudomonas aeruginosa. (PMID 16301811)

Resistomes

Prevalence of MexPQ-OpmE among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI for 82 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).

Prevalence: efflux pump system meta-model

SpeciesNCBI ChromosomeNCBI PlasmidNCBI WGS
No prevalence data


Detection Models

Model Name: MexPQ-OpmE

Model Description: MexPQ-OpmE multidrug efflux pump expressed in Pseudomonas aeruginosa. MexP is the membrane fusion protein; MexQ is the inner membrane transporter; and OpmE is the outer membrane channel.

mexPmexQopmE